Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids - Genetic association analysis
Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids - Genetic association analysis
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DOI：
10.1016/j.atherosclerosis.2013.12.012
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发表时间：
2014-03-01
期刊：
影响因子：
5.3
通讯作者：
Tomaszewski, Maciej
中科院分区：
文献类型：
--
作者：
Bloomer, Lisa D. S.;Nelson, Christopher P.;Tomaszewski, Maciej
目的：在中年男性中，单倍组I与冠状动脉疾病的风险比其他父系Y染色体相关高约50%。我们假设，单倍组I的携带者在生命早期有更高水平的攻击性和雌激素水平和/或更低水平的雄激素，因此可能比其他Y染色体家族的男性更容易患心血管疾病。方法：我们从普通人群中重建了1000名年轻、表面健康的白人男性的Y染色体系统发生树。每条Y染色体都被归类为13个最常见的欧洲血统之一。用放射免疫法测定雄激素(脱氢表雄酮-S、雄烯二酮、总睾酮)及其代谢物(总雌二醇、雌酮)。结果：约17%的男性从父亲那里遗传了单倍组1。单群I携带者的言语攻击得分低于其他单群男性(β=-0.72，SE=0.29，P=0.012)，进一步低于最常见的R1a血统携带者和其他单群携带者(β=-1.03，SE=0.34，P=0.003)。然而，这些关联并没有在多次测试的校正中幸存下来。性激素甚至没有显示出与单倍组I的名义水平的关联。结论：我们的数据显示，在年轻的白人男性中，单倍组I和与性别相关的表型之间没有总体关联。这些结果还表明，之前发现的单倍组I与冠状动脉疾病之间的联系不太可能是由性激素的不利特征或生命早期增强的攻击性所介导的。(C)2014爱思唯尔爱尔兰有限公司。保留所有权利。
Objective: Amongst middle-aged men, haplogroup I is associated with approximate to 50% higher risk of coronary artery disease than other paternal lineages of Y chromosome. We hypothesised that carriers of haplogroup I had higher levels of aggression and estrogens and/or lower levels of androgens early in life and thus might be more prone to cardiovascular disease than men with other lineages of Y chromosome.Methods: We reconstructed phylogenetic tree of the Y chromosome in > 1000 young apparently healthy white men from the general population. Each Y chromosome was classified into one of 13 most common European lineages. Androgens (DHEA-S, androstenedione, total testosterone) and their metabolites (total estradiol, estrone) were measured by radioimmunoassays. Information on five dimensions of aggression (total, physical, verbal, anger and hostility) was collected using Buss and Perry questionnaire.Results: Approximately 17% men inherited haplogroup I from their fathers. Carriers of haplogroup I showed lower scores of verbal aggression than men with other haplogroups (beta = -0.72, SE = 0.29, P = 0.012) and when further compared to carriers of most common R1a lineage and other haplogroups (beta = -1.03, SE = 0.34, P = 0.003). However, these associations did not survive a correction for multiple testing. Sex steroids did not show even nominal level of association with haplogroup I.Conclusion: Our data show no overall association between haplogroup I and sex-related phenotypes in young white men. These results also suggest that the previously identified association between haplogroup I and coronary artery disease is not likely mediated by unfavourable profile of sex steroids or heightened aggression early in life. (C) 2014 Elsevier Ireland Ltd. All rights reserved.