INTER-STUDY DIFFERENCES - HOW SHOULD THEY INFLUENCE THE INTERPRETATION AND ANALYSIS OF RESULTS
INTER-STUDY DIFFERENCES - HOW SHOULD THEY INFLUENCE THE INTERPRETATION AND ANALYSIS OF RESULTS
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DOI：
10.1002/sim.4780060327
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发表时间：
1987-04-01
影响因子：
2
通讯作者：
BAILEY, KR
中科院分区：
文献类型：
--
作者：
BAILEY, KR
在确定研究间变异在综述分析中应发挥的作用时，重要的是要考虑三个因素：（1）试图回答的问题;（2）设计的相似或不相似程度;（3）结果异质性的解释程度。人们可能感兴趣的三个问题是：（1）在某些情况下治疗是否有效;（2）治疗是否平均有效;（3）在手头的试验中，治疗是否平均有效。在没有质的相互作用的假设下，这些问题的答案是一致的。O - E分析最直接地回答了第三个问题.当第一个问题值得关注时，建议进行其他分析，以阿司匹林心肌梗死后研究为例。
In determining the role inter‐study variation should play in an overview analysis, it is important to consider three factors: (1) which question one is trying to answer; (2) the degree of similarity or dissimilarity of design, and (3) the degree to which heterogeneity of outcomes can be explained. Three questions one might be interested in are: (1) whether treatment can be effective in some circumstances; (2) whether treatment is effective on average, and (3) whether treatment was effective on average in the trials at hand. Under the assumption of no qualitative interaction, the answers to these questions coincide. The O – E analysis most directly answers the third question. Other analyses are suggested when the first question is of interest, using the aspirin post‐MI studies as an example.