Influence of interleukin IL-2 and IL-12+IL-18 on surface expression of immunoglobulin-like receptors KIR2DL1, KIR2DL2, and KIR3DL2 in natural killer cells
Influence of interleukin IL-2 and IL-12+IL-18 on surface expression of immunoglobulin-like receptors KIR2DL1, KIR2DL2, and KIR3DL2 in natural killer cells
复制标题
DOI：
10.1155/mi/2006/46957
复制
发表时间：
2006-01-01
影响因子：
4.6
通讯作者：
Bodalski, Jerzy
中科院分区：
文献类型：
--
作者：
Chrul, Slawomir;Polakowska, Ewa;Bodalski, Jerzy
自然杀伤细胞（NK）表达识别多态I类MHC分子的杀伤细胞抑制受体（KIRs）。在本研究中，我们分析了IL-2单独或IL-12与IL-18联合对NK细胞中杀伤细胞免疫球蛋白样受体KIR2DL1、KIR2DL2和KIR3DL2表面表达的调节作用。因此，我们发现IL-2导致具有给定研究受体的细胞比例显著增加。IL-12和IL-18的混合刺激引起具有KIR2DL1和KIR2DL2的细胞比例显著增加，但表面具有KIR3DL2受体的细胞比例没有显著变化。研究结果表明，KIRs存在于静止NK细胞和活化NK细胞中，这可能表明KIRs在激活NK细胞亚群后的调节过程中也起着重要作用。版权所有(c) 2006 Slawomir Chrul等。
Natural killer (NK) cells express killer cell inhibitory receptors (KIRs) that recognize polymorphic class I MHC molecules. In the present study, we analyze the modulatory effect of IL-2 alone or a combination of IL-12 with IL-18 on surface expression of killer cell immunoglobulin-like receptors KIR2DL1, KIR2DL2, and KIR3DL2 in NK cells. Thus, it was found that IL-2 causes a significant increase in the proportion of cells with given studied receptors. Stimulation by a mixture of IL-12 and IL-18 caused significant increase in the fraction of cells with the KIR2DL1 and KIR2DL2, however no significant change in the percentage of cells with KIR3DL2 receptor on their surface was observed. The results of the study show the presence of KIRs on both resting and activated NK cells, this may suggest that KIRs have also an important role in the regulatory processes after activation of this subpopulation of cells. Copyright (c) 2006 Slawomir Chrul et al.