Emotion recognition and inhibitory control in manifest and pre-manifest Huntington's disease: evidence from a new Stroop task
Emotion recognition and inhibitory control in manifest and pre-manifest Huntington's disease: evidence from a new Stroop task
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DOI：
10.4103/1673-5374.274342
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发表时间：
2020-08-01
影响因子：
6.1
通讯作者：
Belardinelli, Marta Olivetti
中科院分区：
文献类型：
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作者：
Hunefeldt, Thomas;Maffi, Sabrina;Belardinelli, Marta Olivetti
亨廷顿病(HD)是一种遗传性神经退行性疾病，不仅影响运动，还影响认知领域。特别是，认知症状，如执行技能受损和在识别他人精神状态方面的缺陷，可能会在运动症状出现多年之前出现。本研究旨在通过一个新的Stroop任务来检验先前研究提出的两个认知假说：1)HD的情绪识别受损受到情绪效价的抑制；2)HD的抑制控制受损。40名显性HD患者和20名显性前期HD患者以及他们的年龄和性别匹配的对照组都完成了传统的Stroop颜色和单词测试(SCWT)和新创建的“Stroop单词干扰任务下的Stroop情绪识别”(SERWIT)，该任务包含120张悲伤、平静或快乐的照片，其中有一致或不一致的单词干扰。在SERWIT量表上，认知障碍的情绪识别受情绪类型的影响较小，在识别悲伤和平静方面的缺陷大于识别快乐的缺陷，但不受刺激一致性的影响。在SCWT上，六个不同的干扰分数产生了许多不同的群体效应模式。总体而言，我们的结果证实了HD患者情绪识别受损受情绪效价影响的假说，但并未为HD患者抑制控制受损的假说提供证据。情绪效价对HD情绪识别受损的调节作用的心理机制还需要进一步的研究，以证实HD患者Stroop任务中的抑制过程没有受到损害的假说。展望这项研究之外，SERWIT承诺为解开神经障碍的认知和精神运动方面做出重要贡献。这项研究于2018年1月24日获得罗马“莱昂纳尔达·瓦卡里研究所”伦理委员会的批准。
Huntington's disease (HD) is a genetic neurodegenerative disorder that affects not only the motor but also the cognitive domain. In particular, cognitive symptoms such as impaired executive skills and deficits in recognizing other individuals' mental state may emerge many years before the motor symptoms. This study was aimed at testing two cognitive hypotheses suggested by previous research with a new Stroop task created for the purpose: 1) the impairment of emotion recognition in HD is moderated by the emotions' valence, and 2) inhibitory control is impaired in HD. Forty manifest and 20 pre-manifest HD patients and their age- and gender-matched controls completed both the traditional "Stroop Color and Word Test" (SCWT) and the newly created "Stroop Emotion Recognition under Word Interference Task" (SERWIT), which consist in 120 photographs of sad, calm, or happy faces with either congruent or incongruent word interference. On the SERWIT, impaired emotion recognition in manifest HD was moderated by emotion type, with deficits being larger in recognizing sadness and calmness than in recognizing happiness, but it was not moderated by stimulus congruency. On the SCWT, six different interference scores yielded as many different patterns of group effects. Overall our results corroborate the hypothesis that impaired emotion recognition in HD is moderated by the emotions' valence, but do not provide evidence for the hypothesis that inhibitory control is impaired in HD. Further research is needed to learn more about the psychological mechanisms underlying the moderating effect of emotional valence on impaired emotion recognition in HD, and to corroborate the hypothesis that the inhibitory processes involved in Stroop tasks are not impaired in HD. Looking beyond this study, the SERWIT promises to make important contributions to disentangling the cognitive and the psychomotor aspects of neurological disorders. The research was approved by the Ethics Committee of the "Istituto Leonarda Vaccari", Rome on January 24, 2018.