The action of radium on cancer cells II - Some factors determining the susceptibility of cancer cells to radium
The action of radium on cancer cells II - Some factors determining the susceptibility of cancer cells to radium
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DOI：
10.1098/rspb.1933.0044
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发表时间：
1933-07-01
期刊：
影响因子：
--
通讯作者：
Cramer, W
中科院分区：
文献类型：
--
作者：
Crabtree, HG;Cramer, W
不同类型的细胞和组织对镭的敏感性是放射治疗的突出问题之一，无论从理论还是从实践的角度来看都是如此。在生物体中，正常组织和恶性组织对短波辐射的反应有很大的不同。一些正常组织，e。G，淋巴腺和测试，非常敏感，而其他的则不那么敏感。在生物体中辐照后，不同的恶性新生长物之间的敏感性也有类似的变化。然而，当研究分离的细胞团时，辐照对正常组织和恶性组织的影响更为均匀。无论是正常成纤维细胞还是肿瘤细胞，组织培养物在辐照后均观察到类似的生物学和形态学变化；在肿瘤组织切片、试验和脾脏中引起的代谢紊乱具有相同的类型和程度（Crabtree, 1932）。
The susceptibility to radium of different types of cells and tissues is one of the outstanding problems of radiotherapy, both from the theoretical and practical points of view. In the organism, normal and malignant tissues exhibit great variations in their response to short-wave radiation. Some normal tissues,e. g., lymph glands and tests, are extremely sensitive, while others are much less so. There are similar variations in sensitivity between different malignant new growths when irradiated in the organism. There is, however, more uniformity in the effects of irradiation on normal and malignant tissues when isolated cell-masses are studied. Similar biological and morphological changes are observed after irradiation of tissues cultures, whether of normal fibroblasts or tumour cells; and the metabolic disturbances induced in slice of tumour tissue, tests and spleen are of the same type and magnitude (Crabtree, 1932).