Looking for reward in all the wrong places: dopamine receptor gene polymorphisms indirectly affect aggression through sensation-seeking
Looking for reward in all the wrong places: dopamine receptor gene polymorphisms indirectly affect aggression through sensation-seeking
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DOI：
10.1080/17470919.2015.1119191
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发表时间：
2016-10-01
影响因子：
2
通讯作者：
Jiang, Yang
中科院分区：
文献类型：
--
作者：
Chester, David S.;DeWall, C. Nathan;Jiang, Yang
具有编码多巴胺能大脑活动减少的基因的个体通常表现出攻击性的倾向。然而，多巴胺能基因型别如何增加攻击性在很大程度上仍不清楚。功能较低的多巴胺系统会促使个人从非法药物和其他危险经历等外部来源寻求回报。根据新出现的证据，攻击是一种有益的经历，我们预测，功能低下的多巴胺能功能对攻击的影响将通过寻求奖励环境的倾向来调节。对高加索男女大学生(N=277)的多巴胺D2受体(DRD2)基因的5个多态进行了基因分型；他们报告了他们既往的攻击史和性情奖赏寻求。功能较差的DRD2档案与更大的感觉寻求有关，这预示着更大的攻击性。我们的发现表明，功能较低的多巴胺能活动会使个人面临暴力的风险，因为它会激励他们体验攻击性的享乐奖励品质。
Individuals with genotypes that code for reduced dopaminergic brain activity often exhibit a predisposition toward aggression. However, it remains largely unknown how dopaminergic genotypes may increase aggression. Lower-functioning dopamine systems motivate individuals to seek reward from external sources such as illicit drugs and other risky experiences. Based on emerging evidence that aggression is a rewarding experience, we predicted that the effect of lower-functioning dopaminergic functioning on aggression would be mediated by tendencies to seek the environment for rewards. Caucasian female and male undergraduates (N=277) were genotyped for five polymorphisms of the dopamine D2 receptor (DRD2) gene; they reported their previous history of aggression and their dispositional reward-seeking. Lower-functioning DRD2 profiles were associated with greater sensation-seeking, which then predicted greater aggression. Our findings suggest that lower-functioning dopaminergic activity puts individuals at risk for violence because it motivates them to experience aggression's hedonically rewarding qualities.