An excitatory-inhibitory fronto-cerebellar loop resolves the Stroop effect
An excitatory-inhibitory fronto-cerebellar loop resolves the Stroop effect
复制标题
DOI：
10.1101/2022.01.18.476551
复制
发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Moe Okayasu;Tensei Inukai;Daiki Tanaka;Kaho Tsumura;Maho Hosono;Reiko Shintaki;Masaki Takeda;K. Nakahara;K. Jimura
中科院分区：
文献类型：
--
作者：
Moe Okayasu;Tensei Inukai;Daiki Tanaka;Kaho Tsumura;Maho Hosono;Reiko Shintaki;Masaki Takeda;K. Nakahara;K. Jimura
斯特鲁普效应是人类众所周知的行为现象，指的是语言和颜色信息之间的强烈干扰。尽管这种效应早已被研究，但仍不清楚干扰何时发生以及如何在大脑中解决。通过操纵刺激感知和反应生成的语言，我们表明斯特鲁普效应发生在颜色词刺激的感知过程中，并通过涉及外侧前额叶皮层和小脑的跨半球的兴奋-抑制功能环路来解决。人类执行斯特鲁普任务和控制任务，其中刺激不包含言语信息，并通过声音或手动做出反应。斯特鲁普干扰的解决涉及左半球的外侧前额皮质和右半球的小脑，与是否通过声音或手动做出反应无关。相比之下，在非语言控制任务中不存在这种跨半球偏侧化。此外，前额叶皮层增强了小脑的活动，而小脑则抑制了前额叶的活动，并且这些效应在干扰解决过程中得到增强。这些结果表明，涉及语言和认知系统的额小脑环路调节与目标相关的信息，以解决同时感知单词和颜色期间发生的干扰。
The Stroop effect is a well-known behavioral phenomenon in humans that refers to robust interference between language and color information. Although this effect has long been studied, it remains unclear when the interference occurs and how it is resolved in the brain. By manipulating the verbality of stimulus perception and response generation, here we show that the Stroop effect occurs during perception of color-word stimuli and is resolved by a cross-hemispheric, excitatory-inhibitory functional loop involving the lateral prefrontal cortex and cerebellum. Humans performed a Stroop task and a control task in which the stimulus did not contain verbal information, and made a response either vocally or manually. The resolution of Stroop interference involved the lateral prefrontal cortex in the left hemisphere and the cerebellum in the right hemisphere, independently of whether the response was made vocally or manually. In contrast, such cross-hemispheric lateralization was absent during the non-verbal control task. Moreover, the prefrontal cortex amplified cerebellar activity, whereas the cerebellum suppressed prefrontal activity, and these effects were enhanced during interference resolution. These results suggest that this fronto-cerebellar loop involving language and cognitive systems regulates goal-relevant information to resolve the interference occurring during simultaneous perception of a word and color.