Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan - The JPHC study
Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan - The JPHC study
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DOI：
10.1007/s10552-007-9002-z
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发表时间：
2007-08-01
影响因子：
2.3
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Luo, Juhua;Iwasaki, Motoki;Tsugane, Shoichiro
目的：在日本进行的一项大型人群队列研究（JPHC研究）中，研究BMI和体力活动对胰腺癌风险的影响。特别是，我们探讨了这些影响是如何受到吸烟状况和糖尿病史的影响的。方法：共99670名参与者（47499名男性，52171名女性），平均随访11年至2003年底。采用Cox比例风险模型估计风险比（HR）及其95%置信区间（CI）。结果：共发现胰腺癌224例（男128例，女96例）。男性患胰腺癌的风险与吸烟史（HR = 1.8, CI 1.1-3.0）和糖尿病史（HR = 2.1, CI 1.3-3.5）相关。在女性中，吸烟（HR = 2.0, CI 0.9-4.4）和糖尿病（HR = 1.5, CI 0.7-3.5）也有类似的风险增加。BMI指数与男性患胰腺癌的风险呈负相关，尤其是在目前的男性吸烟者或糖尿病患者中，但在女性中没有发现相关关系。无论是男性还是女性，休闲时间的体育活动都与风险无关。结论：我们的研究证实了吸烟、糖尿病史和胰腺癌风险增加之间的联系。然而，我们的数据表明，日本人群中BMI与胰腺癌风险之间的关系可能与西方人群不同。
Objective: The effects of BMI and physical activity on the risk of pancreatic cancer were investigated in a large population-based cohort study in Japan (JPHC study). In particular, we explored how these effects were influenced by smoking status and a history of diabetes.Methods: In total, 99,670 participants (47,499 men, and 52,171women) were followed for an average of 11 years through the end of 2003. Hazard ratios (HR) and their 95% confidence intervals (CI) were estimated by Cox proportional hazards models.Results: A total of 224 incident cases (128 men, 96 women) of pancreatic cancer were identified. A statistically significant excess risk of pancreatic cancer was associated with current smoking (HR = 1.8, CI 1.1-3.0) and a history of diabetes (HR = 2.1, CI 1.3-3.5) among men. A similar increase in risk associated with current smoking (HR = 2.0, CI 0.9-4.4) and diabetes (HR = 1.5, CI 0.7-3.5) was also seen among women. BMI was inversely associated with risk of pancreatic cancer among men, especially among current male smokers or diabetes patients, but no association was found among women. Leisure-time physical activity was not associated with risk in either men or women.Conclusions: Our study confirms the association between cigarette smoking, history of diabetes and increased risk of pancreatic cancer. However, our data suggest that the association between BMI and risk of pancreatic cancer in this Japanese population may be different from that in Western populations.