TRANSCRIPTION BY RNA-POLYMERASE-II - A PROCESS LINKED TO DNA-REPAIR
TRANSCRIPTION BY RNA-POLYMERASE-II - A PROCESS LINKED TO DNA-REPAIR
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DOI：
10.1002/bies.950160910
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发表时间：
1994-09-01
期刊：
影响因子：
4
通讯作者：
EGLY, JM
中科院分区：
文献类型：
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作者：
CHALUT, C;MONCOLLIN, V;EGLY, JM
参与蛋白质编码基因基础转录的蛋白质现已被鉴定。虽然对它们的功能知之甚少，但最近的数据表明这些蛋白质（以前称为II类转录因子）参与其他反应的能力：TBP，TATA盒结合因子，参与I类和III类转录，而TFIIH已被证明具有参与DNA修复机制的成分。一些（如果不是全部）TFIIH亚基参与转录和修复可能解释了在着色性干皮病、科凯恩综合征和毛硫营养不良疾病中观察到的各种甚至有时完全不相关的症状的异质性。
The proteins that are implicated in the basal transcription of protein coding genes have now been identified. Although little is known about their function, recent data demonstrate the ability of these proteins, previously called class II transcription factors, to participate in other reactions: TBP, the TATA-box binding factor, is involved in class I and III transcription, while TFIIH has been shown to possess components that are involved in the DNA repair mechanism. The involvement of some if not all of the TFIIH subunits in transcription and repair may explain the heterogeneity of the various and sometimes completely unrelated symptoms observed in xeroderma pigmentosum, Cockayne Syndrome and trichothiodystrophy disorders.