Short-term obesity results in detrimental metabolic and cardiovascular changes that may not be reversed with weight loss in an obese dog model
Short-term obesity results in detrimental metabolic and cardiovascular changes that may not be reversed with weight loss in an obese dog model
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DOI：
10.1017/s0007114514001214
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发表时间：
2014-08-28
影响因子：
3.6
通讯作者：
Weber, Lynn P.
中科院分区：
文献类型：
--
作者：
Adolphe, Jennifer L.;Silver, Tawni I.;Weber, Lynn P.
代谢和心血管变化随体重增加和随后的体重减轻的时间过程尚未阐明。本研究的目的是确定体重增加，体重减轻和身体脂肪分布的改变如何影响肥胖狗模型的代谢和心血管变化。测试是在狗瘦的时候进行的（在9分制中得分为4-5分），在自由喂养12周和32周后促进肥胖（bbb50分），以及体重减轻后进行的。测量包括血清葡萄糖和胰岛素、血浆瘦素、脂联素和c反应蛋白、超声心动图、血流介导扩张和血压。通过计算机断层扫描评估体脂分布。空腹血糖浓度随肥胖显著升高(P
The time course of metabolic and cardiovascular changes with weight gain and subsequent weight loss has not been elucidated. The goal of the present study was to determine how weight gain, weight loss and altered body fat distribution affected metabolic and cardiovascular changes in an obese dog model. Testing was performed when the dogs were lean (scores 4-5 on a nine-point scale), after ad libitum feeding for 12 and 32 weeks to promote obesity (>5 score), and after weight loss. Measurements included serum glucose and insulin, plasma leptin, adiponectin and C-reactive protein, echocardiography, flow-mediated dilation and blood pressure. Body fat distribution was assessed by computed tomography. Fasting serum glucose concentrations increased significantly with obesity (P