PTX3, a prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans
PTX3, a prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans
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DOI：
10.1161/01.cir.102.6.636
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发表时间：
2000-08-08
期刊：
影响因子：
37.8
通讯作者：
Latini, R
中科院分区：
文献类型：
--
作者：
Peri, G;Introna, M;Latini, R
背景-炎症是缺血性心脏病的重要组成部分。PTX 3是一种长五聚蛋白，其表达由内皮细胞、单核吞噬细胞和心肌中的细胞因子诱导。PTX 3在急性心肌梗死（AMI）患者中改变的可能性尚未被tested.Methods和Results-Blood样本收集自37例有AR症状的冠心病监护室（CCU）患者;II。在CCU入院的前24小时内，在27名患者中发现通过ELISA测量的PTX 3血浆浓度高于年龄匹配对照的平均值± 2 SD（2.01 ng/mL）。PTX 3在CCU入院后7.5小时达到峰值，平均峰浓度为6.94+/-11.26 ng/mL。除3例患者外，所有患者的PTX 3血浆浓度在出院时均恢复正常，且与AMI部位或程度、入院时的Killip分级、症状发作后的小时数和溶栓无关。C-反应蛋白在CCU入院后24小时达到峰值，明显晚于PTX 3（P <0.05）。
Background-Inflammation is an important component of ischemic heart disease. PTX3 is a long pentraxin whose expression is induced by cytokines in endothelial cells, mononuclear phagocytes, and myocardium. The possibility that PTX3 is altered in patients with acute myocardial infarction (AMI) has not yet been tested.Methods and Results-Blood samples were collected from 37 patients admitted to the coronary care unit (CCU) with symptoms of AR;II. PTX3 plasma concentrations, as measured by ELISA, higher than the mean+2 SD of age-matched controls (2.01 ng/mL) were found in 27 patients within the first 24 hours of CCU admission. PTX3 peaked at 7.5 hours after CCU admission, and mean peak concentration was 6.94+/-11.26 ng/mL. Plasma concentrations of PTX3 returned to normal in all but 3 patients at hospital discharge and were unrelated to AMI site or extent, Killip class at entry, hours from symptom onset, and thrombolysis. C-reactive protein peaked in plasma at 24 hours after CCU admission, much later than PTX3 (P64 years old and women had significantly higher PTX3 concentrations at 24 hours (P