Insulin resistance in children and adolescents
Insulin resistance in children and adolescents
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DOI：
10.1007/s11154-006-9019-8
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发表时间：
2006-09-01
影响因子：
8.2
通讯作者：
Lee, Joyce M.
中科院分区：
文献类型：
--
作者：
Lee, Joyce M.
据推测，IR 是肥胖与 2 型糖尿病和心血管疾病未来发展之间的重要病理生理联系。多种测量 IR 的方法已在儿童中得到验证，从金标准高胰岛素正常血糖钳夹到基于空腹胰岛素和血糖水平的简单空腹测量。研究表明，儿童 IR 有许多重要的危险因素，包括肥胖和内脏肥胖、种族/民族、青春期、2 型糖尿病家族史、性别以及小于胎龄或早产。然而，肥胖是儿童 IR 的关键危险因素。美国超过 50% 的肥胖青少年患有 IR。对肥胖儿童的 IR 进行正式评估可能是提高减肥药物治疗和慢性病预防功效的重要策略。
IR is hypothesized to be the important pathophysiologic link between adiposity and future development of type 2 diabetes and cardiovascular disease. A variety of methods for measuring IR have been validated in children, from the gold-standard hyperinsulinemic euglycemic clamp, to simple fasting measures based on fasting insulin and glucose levels. Studies have shown that there are a number of important risk factors for IR in children, including adiposity and visceral adiposity, race/ethnicity, puberty, a family history of type 2 diabetes, sex, and being small for gestational age or prematurity. However, obesity represents the critical risk factor for IR in children. Greater than 50% of obese adolescents in the US have IR. Formal assessment of IR in obese children may represent an important strategy for improving the efficacy of pharmacologic therapy for weight loss and chronic disease prevention.