AN APPARENT TANDEM QUADRUPLICATION OF CHROMOSOME-21 IN A CASE OF CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA
AN APPARENT TANDEM QUADRUPLICATION OF CHROMOSOME-21 IN A CASE OF CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA
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DOI：
10.1016/0165-4608(86)90185-8
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发表时间：
1986-11-01
影响因子：
--
通讯作者：
ELSOLH, H
中科院分区：
文献类型：
--
作者：
DUBE, ID;ELSOLH, H
一个儿童ALL的情况下，白血病克隆有两个正常的染色体#21被替换为一个单一的标记染色体，其中包含四个副本的染色体#21串联排列。这份独特的报告进一步强调了21号染色体多拷贝在急性白血病中所起的作用。在一个细胞中观察到标记似乎仅由串联排列的染色体#21的三个拷贝组成，这提出了标记染色体是逐步扩增过程的结果的可能性。
A case of childhood ALL is presented in which the leukemic clone had both normal chromosomes #21 replaced by a single marker chromosome that contained four copies of chromosome #21 arranged in tandem. This unique report further emphasizes the role played by multiple copies of chromosome #21 in acute leukemia. The observation of one cell in which the marker appeared to consist of only three copies of chromosome #21 arranged in tandem raises the possibility that the marker chromosome arose as a result of a stepwise amplification process.