Difference between male and female rats in cholinergic activity of parasympathetic vasodilatation in the masseter muscle
Difference between male and female rats in cholinergic activity of parasympathetic vasodilatation in the masseter muscle
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DOI：
10.1016/j.archoralbio.2009.02.008
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发表时间：
2009-06-01
影响因子：
3
通讯作者：
Izumi, Hiroshi
中科院分区：
文献类型：
--
作者：
Ishii, Hisayoshi;Niioka, Takeharu;Izumi, Hiroshi
我们比较咬肌的血液流动的变化(MBF),下唇(磅力)和颈总动脉(CCABF)电刺激诱发的舌神经(LN),以检查是否高胆碱能活性副交感神经血管舒张的女性是一种特别的咬肌,以及sex-associated胆碱能副交感神经血管舒张的差异是否影响血液流动的监管orofacial urethane-anaesthetized CCABF的区域,迷走神经交感切除的雄性和雌性大鼠。LN刺激引起的MBF、LBF和CCABF的增加似乎是通过激活副交感神经反射血管扩张介导的，因为自主胆碱能神经节阻滞剂六甲铵（10mg /kg）预处理可以大大降低这些增加。尽管-和-肾上腺素能受体拮抗剂（酚妥拉明和心得安，100 μ g/kg）对LN刺激诱导的血流量增加没有影响，但抗毒蕈碱剂阿托品（1-100 μ g/kg）对这些血流量增加的影响在男性和女性之间存在显著差异。在男性中，阿托品预处理略微减弱了MBF的增加，但在女性中，它显著降低了所有三个测量部位的增加，尤其是MBF。我们的研究结果表明：(1)在大多数口面部组织中，女性副交感神经血管舒张的胆碱能活性高于男性，尤其是在咬肌中；(2)胆碱能副交感神经血管舒张更多地参与到口面部血流的调节中。女性的CCABF面积大于男性。2009爱思唯尔有限公司版权所有。
We compared the changes in blood flow of the masseter muscle (MBF), lower lip (LBF) and common carotid artery (CCABF) evoked by electrical stimulation of the lingual nerve (LN) in order to examine whether high cholinergic activity of parasympathetic vasodilatation in females is specific for the masseter muscle, and whether sex-associated differences in cholinergic parasympathetic vasodilatation affect the regulation of blood flow to the orofacial area from the CCABF in urethane-anaesthetized, vago-sympathectomized male and female rats. Increases in the MBF, LBF and CCABF evoked by LN stimulation appear to be mediated via an activation of parasympathetic reflex vasodilatation since these increases were profoundly reduced by pretreatment with the autonomic cholinergic ganglion blocker hexamethonium (10 mg/kg). Although alpha- and beta-adrenoceptor antagonists (phentolamine and propranolol, 100 mu g/kg) had no effect on the LN stimulation-induced blood flow increases in either sex, a marked difference was found between males and females in the effects of the antimuscarinic agent atropine (1-100 mu g/kg) on these blood flow increases. Pretreatment with atropine slightly attenuated the increase in the MBF in males, but in females it markedly reduced the increases in all three sites measured, especially in the MBF. Our results suggest that (1) cholinergic activity of the parasympathetic vasodilatation in females is higher than that in males in most orofacial tissues, but particularly in the masseter muscle and (2) cholinergic parasympathetic vasodilatations are more involved in the regulation of blood flow to the orofacial. area from the CCABF in females than in males. (C) 2009 Elsevier Ltd. All rights reserved.