Creation of a large deletion mutant of Campylobacter jejuni reveals that the lipooligosaccharide gene cluster is not required for viability.
Creation of a large deletion mutant of Campylobacter jejuni reveals that the lipooligosaccharide gene cluster is not required for viability.
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空肠弯曲杆菌大缺失突变体的创建表明，脂寡糖基因簇并不是生存所必需的。
DOI：
10.1128/jb.01397-08
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发表时间：
2009
影响因子：
3.2
通讯作者：
Marsden GL
中科院分区：
文献类型：
--
作者：
Marsden GL
从空肠弯曲菌NCTC 11168基因组中缺失脂寡糖生物合成区域（Cj1132c至Cj1152c）表明核心对于生存力不是必需的。该突变体的生长减弱，对抗生素和洗涤剂的敏感性增加。培养的宿主细胞的自然转化和侵袭被消除。
Deletion of the lipooligosaccharide biosynthesis region (Cj1132c to Cj1152c) from the genome ofCampylobacter jejuniNCTC11168 shows that the core is not required for viability. The mutant was attenuated for growth and has increased sensitivity to antibiotics and detergents. Natural transformation and invasion of cultured host cells was abolished.