Residential and occupational exposure to sunlight and mortality from non-Hodgkin's lymphoma: Composite (threefold) case-control study
Residential and occupational exposure to sunlight and mortality from non-Hodgkin's lymphoma: Composite (threefold) case-control study
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DOI：
10.1136/bmj.314.7092.1451
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发表时间：
1997-05-17
影响因子：
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通讯作者：
Dosemeci, M
中科院分区：
文献类型：
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作者：
Freedman, DM;Zahm, SH;Dosemeci, M
目的：确定非霍奇金淋巴瘤死亡率是否与阳光照射有关。设计：三项病例对照研究基于非霍奇金淋巴瘤、黑色素瘤和皮肤癌死亡率的死亡证明，研究居住和职业中潜在的阳光照射与死亡率的关系。背景：美国24个州。研究对象：所有病例均为1984年至1991年间死于非霍奇金淋巴瘤、黑色素瘤和非黑色素皮肤癌的病例。从非癌症死亡病例中选择两个年龄、性别和种族频率匹配的对照。主要结局指标：根据年龄、性别、种族、社会经济地位和农业职业调整的居住和职业阳光照射导致的非霍奇金淋巴瘤、黑色素瘤和皮肤癌的优势比。结果：非霍奇金淋巴瘤死亡率与居住地点的日照暴露无正相关。黑色素瘤和皮肤癌都与居住阳光照射呈正相关。居住在阳光照射最多的州的校正比值比是非霍奇金淋巴瘤为0.83(95%可信区间0.81至0.86)，黑色素瘤为1.12(1.06至1.19)，皮肤癌为1.30（1.18至1.43）。此外，非霍奇金淋巴瘤死亡率与职业性阳光照射无正相关（优势比0.88;0.81 - 0.96）。皮肤癌与职业性阳光照射有轻微正相关（1.14；0.96至1.36）。结论：与皮肤癌和某种程度上的黑色素瘤不同，非霍奇金淋巴瘤的死亡率与阳光照射没有正相关。因此，研究结果不支持阳光照射导致非霍奇金淋巴瘤发病率上升的假设。
Objective: To determine whether non-Hodgkin's lymphoma mortality is associated with sunlight exposure.Design: Three case-control studies based on death certificates of non-Hodgkin's lymphoma, melanoma, and skin cancer mortality examining associations with potential sunlight exposure from residence and occupation.Setting: 24 states in the United States.Subjects: All cases were deaths from non-Hodgkin's lymphoma, melanoma, and non-melanotic skin cancer between 1984 and 1991. Two age, sex, and race frequency matched controls per case were selected from non-cancer deaths.Main outcome measures: Odds ratios for non-Hodgkin's lymphoma, melanoma, and skin cancer from residential and occupational sunlight exposure adjusted for age, sex, race, socioeconomic status, and farming occupation.Results: Non-Hodgkin's lymphoma mortality was not positively associated with sunlight exposure based on residence. Both melanoma and skin cancer were positively associated with residential sunlight exposure. Adjusted odds ratios for residing in states with the highest sunlight exposure were 0.83 (95% confidence interval 0.81 to 0.86) for non-Hodgkin's lymphoma, 1.12 (1.06 to 1.19) for melanoma, and 1.30 (1.18 to 1.43) for skin cancer. In addition, non-Hodgkin's lymphoma mortality was not positively associated with occupational sunlight exposure (odds ratio 0.88; 0.81 to 0.96). Skin cancer was slightly positively associated with occupational sunlight exposure (1.14; 0.96 to 1.36).Conclusions: Unlike skin cancer and to some extent melanoma, non-Hodgkin's lymphoma mortality was not positively associated with exposure to sunlight The findings do not therefore support the hypothesis that sunlight exposure contributes to the rising rates of non-Hodgkin's lymphoma.