An update on the physiologic changes during pregnancy and their impact on drug pharmacokinetics and pharmacogenomics.
An update on the physiologic changes during pregnancy and their impact on drug pharmacokinetics and pharmacogenomics.
复制标题
DOI：
10.1515/jbcpp-2021-0312
复制
发表时间：
2022-09-01
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
多年来，医学界在临床实践中一直依赖于有关怀孕期间发生的生理变化的历史数据。然而，一些较新的研究对这些数据中的一些假设提出了质疑，认为这些假设不是基于证据的，也不是来自大型前瞻性队列研究。准确了解这些生理变化很重要，原因有三：第一，它有助于正确诊断妊娠期间的疾病;第二，它使我们能够回答有关妊娠期间药物作用以及妊娠改变药代动力学和药物作用的方式的问题;第三，它允许基于生理学的药代动力学模型的适当建模，其越来越多地用于预测妊娠特异性变化和药物-药物相互作用，以及开发关于药物作用模式、其相互作用的机制以及药物暴露后的任何不良反应的新知识。本文回顾了新的证据有关的生理变化在怀孕期间与现有的知识。
For many years, the medical community has relied in clinical practice on historic data about the physiological changes that occur during pregnancy. However, some newer studies have disputed a number of assumptions in these data for not being evidence-based or derived from large prospective cohort-studies. Accurate knowledge of these physiological changes is important for three reasons: Firstly, it facilitates correct diagnosis of diseases during pregnancy; secondly, it enables us to answer questions about the effects of medication during pregnancy and the ways in which pregnancy alters pharmacokinetic and drug-effects; and thirdly, it allows for proper modeling of physiologically-based pharmacokinetic models, which are increasingly used to predict gestation-specific changes and drug–drug interactions, as well as develop new knowledge on the mode-of-action of drugs, the mechanisms underlying their interactions, and any adverse effects following drug exposure. This paper reviews new evidence regarding the physiologic changes during pregnancy in relation to existing knowledge.
影响因子：
2
作者：
Jenkins PC;Stokes SM;Fakoyeho S;Bell TM;Zarzaur BL
通讯作者：
Zarzaur BL