ABNORMALITY OF LEU 2+7+ CELLS IN ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME (AIDS), AIDS-RELATED COMPLEX, AND ASYMPTOMATIC HOMOSEXUALS
ABNORMALITY OF LEU 2+7+ CELLS IN ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME (AIDS), AIDS-RELATED COMPLEX, AND ASYMPTOMATIC HOMOSEXUALS
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DOI：
10.1007/bf00915256
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发表时间：
1986-11-01
影响因子：
9.1
通讯作者：
GUPTA, S
中科院分区：
文献类型：
--
作者：
GUPTA, S
分析了获得性免疫缺陷综合征（AIDS）和AIDS相关综合征（ARC）患者、无症状同性恋者和健康异性恋者外周血单个核细胞中Leu 7+细胞和双标记Leu 2+7+细胞的比例和数量以及自然杀伤功能。与健康的异性恋男性相比，在艾滋病和ARC患者和无症状的同性恋者中观察到Leu 7+细胞的比例和数量显着增加。Leu 2+7+细胞的比例在AIDS、ARC和无症状的同性恋者中显著增加，而在无症状的同性恋者和ARC中Leu 2 + 7+细胞的数量增加，但在AIDS中没有增加。Leu 2+7+细胞数量在AIDS合并Kaposis肉瘤中显著增加，但在AIDS合并机会性感染中未观察到。自然杀伤细胞功能在艾滋病和ARC患者和无症状的同性恋者中显著降低。这些数据表明，Leu 2+7+细胞的数量异常出现在HTLV III/LAV感染的免疫变化的演变过程中的早期。
Peripheral blood mononuclear cells from patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), asymptomatic homosexuals, and healthy heterosexuals were analyzed for the proportions and numbers of Leu 7+ cells and double-labeled Leu 2+7+ cells and for the natural killer functions. A significant increase in the proportions and numbers of Leu 7+ cells was observed in patients with AIDS and ARC and in asymptomatic homosexuals compared to healthy heterosexual men. The proportions of Leu 2+7+ cells were significantly increased in AIDS, ARC, and asymptomatic homosexuals, whereas the numbers were increased in asymptomatic homosexuals and ARC but not in AIDS compared to heterosexual controls. A significant increase in the number of Leu 2+7+ cells were observed in AIDS with Kaposi''s sarcoma but not in AIDS with opportunistic infections. The natural killer function was significantly depressed in patients with AIDS and ARC and in asymptomatic homosexuals. These data suggest that the quantitative abnormalities of Leu 2+7+ cells appear early during the evolution of immunologic changes in HTLV III/LAV infection.