High prevalence of hyperhomocysteinemia in Chinese adults is associated with low folate, vitamin B-12, and vitamin B-6 status
High prevalence of hyperhomocysteinemia in Chinese adults is associated with low folate, vitamin B-12, and vitamin B-6 status
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DOI：
10.1093/jn/137.2.407
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发表时间：
2007-02-01
影响因子：
4.2
通讯作者：
Li, Zhu
中科院分区：
文献类型：
--
作者：
Hao, Ling;Ma, Jing;Li, Zhu
血浆总同型半胱氨酸（tHcy）浓度升高与叶酸、维生素B-12和维生素B-6水平降低相关，在发达国家被认为是心血管疾病的独立危险因素，但在发展中国家的数据有限。我们进行了一项横断面研究，以探讨tHcy状态及其与血浆B族维生素状态的关系，在2471名中国男性和女性，年龄在35至64岁之间，生活在中国北方和南方的城市和农村地区。还在两个季节（春季和秋季）采集血样。在控制性别、地区（城市和农村）、年龄和季节（春季和秋季）后，北方人群血浆tHcy浓度的几何平均值（校正后的几何平均值，95%CI，13.0 μ mol/L，12.6-13.3）显著高于南方人群（9.1，8.9-9.4）。28%的北方人和7%的南方人的血浆tHcy浓度>= 16.0 μ mol/L，这一水平用于定义高同型半胱氨酸血症。在每个地区内，男性的血浆tHcy浓度高于女性（北方为16.1 μ mol/L，南方为10.7 μ mol/L，南方为7.9 μ mol/L），北方40%的男性患有高同型半胱氨酸血症。一般而言，生活在城市地区的个体比生活在农村地区的个体具有高tHcy水平（>= 16 μ mol/L）的几率高30%（95%CI，1.0-1.6）。血浆叶酸、维生素B-12和B-6浓度低、年龄大、患有梅斯病和生活在城市地区均与tHcy升高独立相关，低叶酸是最强的决定因素。
Elevated plasma total homocysteine (tHcy) concentrations are associated with lower folate, vitamin B-12, and vitamin B-6 status and are considered an independent risk factor for cardiovascular disease in developed countries, but data in developing countries are limited. We conducted a cross-sectional study to explore tHcy status and its association with plasma B vitamin status in 2471 Chinese men and women aged 35 to 64 y, living in the urban and rural areas of the northern and the southern regions of China. Blood samples were also collected in 2 seasons (spring and fall). The geometric mean plasma tHcy concentration was significantly higher in the north (adjusted geometric mean, 95% CI, 13.0 mu mol/L, 12.6-13.3) than in the south (9.1, 8.9-9.4) after controlling for gender, area (urban and rural), age, and season (spring and fall). Twenty-eight percent of northerners and 7% of southerners had plasma tHcy concentrations >= 16.0 mu mol/L, a level used to define hyperhomocysteinemia. Within each region, men had higher plasma tHcy concentrations than women (16.1 vs. 10.6 mu mol/L in the north, and 10.7 vs. 7.9 mu mol/L in the south) and 40% of the northern men had hyperhomocysteinemia. Generally, individuals living in the urban areas had 30% (95% CI, 1.0-1.6) greater odds of having high tHcy levels (>= 16 mu mol/L) than those living in the rural areas. Low plasma concentrations of folate, vitamins B-12 and B-6, older age, being mace, and living in urban areas were all independently associated with elevated tHcy, with low folate as the strongest determinant.