PLASMA GLUCOSE NON-ESTERIFIED FATTY ACID + INSULIN CONCENTRATIONS IN HYPOTHALAMIC-HYPERPHAGIC RATS
PLASMA GLUCOSE NON-ESTERIFIED FATTY ACID + INSULIN CONCENTRATIONS IN HYPOTHALAMIC-HYPERPHAGIC RATS
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DOI：
10.1042/bj0900620
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发表时间：
1964-01-01
影响因子：
4.1
通讯作者：
KENNEDY, GC
中科院分区：
文献类型：
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作者：
HALES, CN;KENNEDY, GC
诱导大鼠下丘脑腹内侧核的损伤导致摄食过度的发展。与类似处理的假手术对照组相比，允许无限制进食24小时，随后饥饿24小时的处理动物显示血糖、非酯化脂肪酸和胰岛素浓度无可检测的差异。将连续7天无限制进食的贪食大鼠与相同年龄和性别的未处理动物进行比较，结果显示，在进食状态下，非酯化脂肪酸和胰岛素的血浆浓度显著增加;血浆葡萄糖浓度低于对照组，但饥饿24小时后，血浆胰岛素浓度显著升高，葡萄糖和非酯化脂肪酸的血浆浓度没有变化。将允许无限制获取食物3个月的高吞噬大鼠与相同年龄和性别的未治疗动物进行比较，结果显示：在进食状态下，非酯化脂肪酸和胰岛素的血浆浓度显着较高;饥饿24小时后，血浆浓度持续增加非酯化脂肪酸和胰岛素的浓度。
The induction of lesions of the ventromedial nuclei of the hypothalamus in rats led to the development of hyperphagia. Treated animals allowed unlimited access to food for 24 hours followed by 24 hours of starvation showed no detectable difference in the concentrations of plasma glucose, non-esterified fatty acid and insulin in comparison with similarly treated sham-operated controls. Hyperphagic rats allowed unlimited access to food for 7 days were compared with untreated animals of the same age and sex and showed in the fed state significant increases of the plasma concentrations of non-esterified fatty acid and insulin; the plasma glucose concentration was lower than that of the controls but this difference was not statistically significant after starvation for 24 hours a significant increase of the plasma insulin concentration with no change in the plasma concentrations of glucose and non-esterified fatty acid. Hyperphagic rats allowed unlimited access to food for 3 months were compared with untreated animals of the same age and sex and showed: in the fed state significantly higher plasma concentrations of non-esterified fatty acid and insulin; after starvations for 24 hours a persistent increase of the plasma concentrations of non-esterified fatty acid and insulin.