Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care
Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care
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DOI：
10.1159/000442975
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发表时间：
2016-01-01
影响因子：
3.2
通讯作者：
Witchel, Selma
中科院分区：
文献类型：
--
作者：
Lee, Peter A.;Nordenstrom, Anna;Witchel, Selma
关于性发育障碍（dsd）患者的诊断和护理的这一更新的目标是解决自2005年共识会议以来临床方法的变化，因为知识和观点发生了变化。已努力吸纳来自广泛观点的代表，包括支助和倡导团体。患者护理的目标是关注尽可能高的生活质量（QoL）。DSD领域正在不断发展。一个更新的临床评估婴儿和老年人与模糊的生殖器，包括关于男性或女性分配的看法进行了讨论。主题包括生化和遗传评估，生殖细胞肿瘤发展的风险，社会心理和性心理健康的方法以及支持团体的最新情况。与患者和家长进行开放和持续的沟通必须包括充分披露，并认识到，虽然DSD条件是终身的，但提高最佳可能的结果可以改善生活质量。诊断和护理的发展仍在继续，但仍不可能确定地预测个别病例的性别发展。这类决定以及有关婴儿期手术改变外生殖器解剖结构或移除生殖细胞的决定仍然存在风险。(C) 2016 S. Karger AG，巴塞尔
The goal of this update regarding the diagnosis and care of persons with disorders of sex development (DSDs) is to address changes in the clinical approach since the 2005 Consensus Conference, since knowledge and viewpoints change. An effort was made to include representatives from a broad perspective including support and advocacy groups. The goal of patient care is focused upon the best possible quality of life (QoL). The field of DSD is continuously developing. An update on the clinical evaluation of infants and older individuals with ambiguous genitalia including perceptions regarding male or female assignment is discussed. Topics include biochemical and genetic assessment, the risk of germ cell tumor development, approaches to psychosocial and psychosexual well-being and an update on support groups. Open and on-going communication with patients and parents must involve full disclosure, with the recognition that, while DSD conditions are life-long, enhancement of the best possible outcome improves QoL. The evolution of diagnosis and care continues, while it is still impossible to predict gender development in an individual case with certainty. Such decisions and decisions regarding surgery during infancy that alters external genital anatomy or removes germ cells continue to carry risk. (C) 2016 S. Karger AG, Basel