Antibiotics potentially used in response to bioterrorism and the risk of major congenital malformations.
Antibiotics potentially used in response to bioterrorism and the risk of major congenital malformations.
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DOI：
10.1111/j.1365-3016.2008.00978.x
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发表时间：
2009-01
影响因子：
2.8
通讯作者：
Ray WA
中科院分区：
文献类型：
--
作者：
Cooper WO;Hernandez-Diaz S;Arbogast PG;Dudley JA;Dyer SM;Gideon PS;Hall KS;Kaltenbach LA;Ray WA
这项研究旨在评估妊娠相关暴露于生物恐怖袭击事件中推荐使用的抗生素与重大先天性畸形之间的关联。一项回顾性队列研究包括来自田纳西州医疗补助计划的30,049名婴儿，这些婴儿出生于1985年至2000年之间，从计算机化的州数据库中识别出来。将胎儿暴露于环丙沙星、阿奇霉素、多西环素、阿莫西林（推荐用于潜在生物恐怖袭击的抗生素）和红霉素（作为阳性对照）的婴儿与胎儿未暴露于任何抗生素的婴儿进行比较。通过病历审查确认了从计算机记录中识别的主要先天性畸形。总体而言，该队列中有869名（2.9%）婴儿患有经证实的重大先天性畸形，在特定暴露组中，重大畸形的比例为2.5%-3.0%。在多变量分析中，任何畸形和特定器官系统畸形的风险均未增加。总之，这些数据表明，孕妇使用环丙沙星，阿奇霉素，多西环素或阿莫西林不应该导致婴儿的总体重大先天性畸形的发生率较高，母亲服用这些药物，虽然不能排除风险大幅增加。
This study was designed to assess the association between pregnancy-related exposures to antibiotics recommended for use in the event of a bioterrorism attack and major congenital malformations. A retrospective cohort study included 30,049 infants from Tennessee Medicaid born between 1985–2000 identified from computerized state databases. Infants with fetal exposures to ciprofloxacin, azithromycin, doxycycline, and amoxicillin (antibiotics recommended for potential bioterrorism attacks) and erythromycin (included as a positive control) were compared to infants with no fetal exposure to any antibiotics. Major congenital malformations identified from computerized records were confirmed through medical record review. Overall, 869 (2.9%) of infants in the cohort had a confirmed major congenital malformation, with major malformations ranging from 2.5%–3.0% among the antibiotic-specific exposure groups. No increased risk was present in multivariable analyses for any malformations and for malformations of specific organ systems. In conclusion, these data suggest that ciprofloxacin, azithromycin, doxycycline, or amoxicillin use by pregnant women should not result in a greater incidence of overall major congenital malformations in infants whose mothers take these medications, though a large increase in risk cannot be ruled out.
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影响因子：
1.9
作者：
LANE, PW;NELDER, JA
通讯作者：
NELDER, JA
影响因子：
2.8
作者：
Cooper, WO;Hickson, GB;Ray, WA
通讯作者：
Ray, WA
影响因子：
7.2
作者：
Nahum, Gerard G.;Uhl, Kathleen;Kennedy, Dianne L.
通讯作者：
Kennedy, Dianne L.
影响因子：
6.2
作者：
Gross, CP;Filardo, G;Krumholz, HM
通讯作者：
Krumholz, HM
影响因子：
3
作者：
LEISTER, KA;EDWARDS, WAD;CLARK, H
通讯作者：
CLARK, H