Obesity and risk of differentiated thyroid cancer: A large-scale case-control study
Obesity and risk of differentiated thyroid cancer: A large-scale case-control study
复制标题
肥胖与分化型甲状腺癌的风险：一项大规模病例对照研究
DOI：
10.1111/cen.14091
复制
发表时间：
2019-12-01
影响因子：
3.2
通讯作者：
Liang, Nan
中科院分区：
文献类型：
--
作者：
He, Qiao;Sun, Hui;Liang, Nan
目的近年来，甲状腺癌和肥胖的发病率在世界范围内急剧上升。肥胖是否导致分化型甲状腺癌(DTC)的发展仍有争议。我们评估了人体测量值与DTC风险之间的关系。设计/患者/测量基于医院数据进行了一项大型频率匹配病例对照研究。共纳入10 668例DTC患者和11 858例对照。计算体重指数（BMI）、体表面积（BSA）和体脂率（BF%）。采用无条件logistic回归模型。结果单因素分析显示，随着身高、体重、BMI、BSA和BF%的增加，DTC风险显著增加。多变量分析也显示出正相关。根据中国BMI （CN-BMI）分类，各年龄段女性中，超重和肥胖的DTC风险的or分别为1.151（1.037 ~ 1277）和1.292（1.092 ~ 1.528）。50岁以下男性的or值分别为1.221（1.014 ~ 1.469）和1.520(1.202 ~ 1.923)，50岁以上男性的or值无统计学意义。此外，在50岁以下的男性和女性中，BSA与DTC风险显著相关（P = 0.02和P < 0.001）。BF%仅在50岁以下女性中保持显著性（P = 0.003）。然而，对于50岁以上的男性和女性，BSA和BF百分比与DTC风险均无显著相关性。根据世界卫生组织BMI （WHO-BMI）分类，对于50岁以上的所有女性和男性，结果与CN-BMI一致。对于50岁以下的男性，BF%，而不是BMI，显示出与DTC风险的显著关联。结论BMI、BSA、BF%与DTC发生风险呈正相关，且受年龄和性别的影响。
Objective Recently, the incidence of thyroid cancer as well as obesity has dramatically increased worldwide. Whether obesity contributes to the development of differentiated thyroid cancer (DTC) remains controversial. We evaluated the relationship between anthropometric measurements and DTC risk. Design/Patients/Measurements A large frequency-matched case-control study based on hospital data was performed. A total of 10 668 DTC patients and 11 858 controls were enrolled. Body mass index (BMI), body surface area (BSA) and body fat percentage (BF%) were calculated. An unconditional logistic regression model was applied. Results The univariate analysis showed a significant increase in DTC risk with increased height, weight, BMI, BSA and BF%. The multivariate analysis also showed a positive relationship. Based on the Chinese BMI (CN-BMI) classification, for women of all ages, the ORs for DTC risk in overweight and obesity were 1.151 (1.037-1277) and 1.292 (1.092-1.528), respectively. For men under 50, the ORs were 1.221 (1.014-1.469) and 1.520 (1.202-1.923), respectively, but the ORs for men over 50 were not significant. Additionally, BSA showed a significant association with DTC risk for both sexes under 50 (P = .02 and P < .001). BF% remained significant only for women under 50 (P = .003). However, for both sexes over 50, neither BSA nor BF% was significantly associated with DTC risk. Based on The World Health Organization BMI (WHO-BMI) classification, for all women and men over 50, the results were consistent with CN-BMI. For men under 50, BF%, but not BMI, showed a significant association with DTC risk. Conclusion BMI, BSA and BF% were positively correlated with the risk of DTC, which was potentially affected by age and sex.