Dietary acrylamide and human cancer
Dietary acrylamide and human cancer
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DOI：
10.1002/ijc.21336
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发表时间：
2006-01-15
影响因子：
6.4
通讯作者：
La Vecchia, C
中科院分区：
文献类型：
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作者：
Pelucchi, C;Galeone, C;La Vecchia, C
在高温下烹饪的几种食物中发现了低水平的丙烯酰胺。虽然有足够的证据表明丙烯酰胺在实验动物中具有致癌性，但迄今为止对丙烯酰胺的职业和饮食暴露进行的少数流行病学研究没有发现与人类癌症风险相关的一致证据。利用意大利和瑞士医院病例对照研究综合网络的数据，我们分析了饮食中丙烯酰胺摄入量与口腔癌和咽癌之间的关系（749例病例，1，772例对照），食管（395例，1,066例对照），大肠，（结肠癌1，394例，直肠癌886例，对照组4，765例），喉（527例，1，297例对照），乳腺（2，900例，3，122例对照），卵巢（1，031例，2，411例对照）和前列腺（1，294例，1，451例对照）。所有的研究都包括了在同一个医院网络中因急性非肿瘤性疾病而入院的经组织学证实的癌症病例和对照组。我们使用多变量逻辑回归模型计算比值比（OR），并对能量摄入和其他主要相关协变量进行调整。丙烯酰胺摄入量最高与最低五分位数的OR为1.12（95% CI = 0.76-1.66）口腔/咽癌，1.10（95% CI = 0.65-1.86）食管，0.97（95% CI = 0.80-1.18）结直肠，1.23喉癌为1.06（95%CI = 0.88 -1.28），卵巢癌为0.97（95%CI = 0.73-1.31），前列腺癌为0.92（95%CI = 0.69-1.23）。风险趋势均不显著。这个独特的大而全面的数据集并没有显示丙烯酰胺的摄入量与乳腺癌和其他几种常见癌症的风险之间存在任何一致的关联。(c)2005 Wiley-Liss，Inc.
Low levels of acrylamide have been found in several foods cooked at high temperatures. While there is sufficient evidence for the carcinogenicity of acrylamide in experimental animals, the few epidemiologic studies conducted to date on occupational and dietary exposure to acrylamide have found no consistent evidence of association with human cancer risk. Using data from an integrated network of Italian and Swiss hospital-based case-control studies, we analyzed the relation between dietary acrylamide intake and cancers of the oral cavity and pharynx (749 cases, 1,772 controls), esophagus (395 cases, 1,066 controls), large bowel, (1,394 cases of colon, 886 cases of rectal cancer, 4,765 controls), larynx (527 cases, 1,297 controls), breast (2,900 cases, 3,122 controls), ovary (1,031 cases, 2,411 controls) and prostate (1,294 cases, 1,451 controls). All the studies included incident, histologically confirmed cancer cases and controls admitted to the same network of hospitals for acute nonneoplastic conditions. We calculated odds ratios (ORs) using multivariate logistic regression models, adjusted for energy intake and other major covariates of interest. The ORs for the highest versus the lowest quintile of acrylamide intake were 1.12 (95% CI = 0.76-1.66) for cancer of the oral cavity/pharynx, 1.10 (95% CI = 0.65-1.86) for esophageal, 0.97 (95% CI = 0.80-1.18) for colorectal, 1.23 (95% CI = 0.80-1.90) for laryngeal, 1.06 (95% CI = 0.88-1.28) for breast, 0.97 (95% CI = 0.73-1.31) for ovarian and 0.92 (95% CI = 0.69-1.23) for prostate cancer. None of the trend in risk was significant. This uniquely large and comprehensive data set does not show any consistent association between intake of acrylamide and the risk of breast and several other common cancers. (c) 2005 Wiley-Liss, Inc.