Intra-individual variability of high-sensitivity C-reactive protein - Age-related variation over time in Japanese subjects
Intra-individual variability of high-sensitivity C-reactive protein - Age-related variation over time in Japanese subjects
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DOI：
10.1253/circj.70.559
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发表时间：
2006-05-01
影响因子：
3.3
通讯作者：
Kagamimori, S
中科院分区：
文献类型：
--
作者：
Nasermoaddeli, A;Sekine, M;Kagamimori, S
背景前瞻性研究已经证明高敏C反应蛋白（hsCRP）的基线水平与心血管疾病的发生风险之间存在直接关联。潜在的hsCRP的变异性在后续的时间间隔是非常感兴趣的，所以在男性和女性的hsCRP的测量的可重复性，并在不同的年龄组，在本study.Methods和结果hsCRP的测量进行了899名男性和780名女性日本公务员，年龄在18-60岁，在2004年和2005年的春天。受试者内重复性和组内相关系数的可靠性被用来表征测量的变化。测量过程的误差可忽略不计，因为分析方差为0.0003 [ln（mg/L）] [In（mg/L）]，可靠性系数为0.997。相比之下，hsCRP的受试者内变异相当大，男性和女性的可靠性系数均为0.61，重复性系数分别为5.25和5.38。随着年龄的变化不同，特别是在妇女中，作为较少的变化是观察到在40岁以上的受试者在随访interval.Conclusions的结果表明，一个单一的测量hsCRP是受相当大的，但平等的受试者内的变化，随着时间的推移，在男性和女性，这种变化不同的年龄组，这可能影响hsCRP与未来心血管事件相关的风险评估。
Background Prospective studies have demonstrated a direct association between the baseline level of high-sensitivity C-reactive protein (hsCRP) and the risk of developing cardiovascular disease. The potential for hsCRP variability during the follow-up interval is of great interest, so the repeatability of measurements of hsCRP in men and women, and in different age groups, was investigated in the present study.Methods and Results The measurement of hsCRP was performed in 899 male and 780 female Japanese civil servants aged 18-60 years in the spring of 2004 and 2005. Within-subject repeatability and intra-class correlation coefficient of reliability were used to characterize the variation in measurements. Error of the measurement process was negligible, as the analytical variance was 0.0003 [ln(mg/L)] [In(mg/L)] with a reliability coefficient of 0.997. In contrast, the within-subject variation of hsCRP was considerable with a reliability coefficient of 0.61 in both sexes and repeatability coefficients of 5.25 and 5.38 in men and women, respectively. The variation differed with age, especially in women, as less variation was observed in subjects over 40 years of age during the follow-up interval.Conclusions The results suggest that a single measurement of hsCRP is subject to considerable but equal within-subject variation over time in men and women, and this variation differs among the age groups, which may affect the risk assessment of hsCRP in association with future cardiovascular events.