THE ANTINATRIURETIC ACTION OF BIOSYNTHETIC HUMAN GROWTH-HORMONE IN MAN INVOLVES ACTIVATION OF THE RENIN-ANGIOTENSIN SYSTEM
THE ANTINATRIURETIC ACTION OF BIOSYNTHETIC HUMAN GROWTH-HORMONE IN MAN INVOLVES ACTIVATION OF THE RENIN-ANGIOTENSIN SYSTEM
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DOI：
10.1016/0026-0495(90)90065-k
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发表时间：
1990-02-01
影响因子：
9.8
通讯作者：
WEISSBERGER, AJ
中科院分区：
文献类型：
--
作者：
HO, KY;WEISSBERGER, AJ
先前使用人垂体提取物的研究尚未解决人生长激素 (hGH) 的钠保留作用是否部分由醛固酮分泌增加介导。我们研究了真正的生物合成 GH (bio-hGH) 制剂对钠代谢和肾素-血管紧张素系统活性的影响。六名年轻男子连续五天按 0.2 U/kg/d 皮下注射该制剂。收集二十四小时的尿液用于测量钠排泄和渗透压，收集血液用于定量钠、渗透压、血浆肾素活性（PRA）、醛固酮和精氨酸加压素（AVP）浓度的变化。 Bio-hGH 给药导致 24 小时尿钠排泄量下降（197 ± 38 至 42 ± 20 mmol，平均值 ± SD，P < .005），尿量减少（1,652 ± 182 至 848 ± 348 mL，P < .05），但渗透压没有下降。 PRA 从 1,118 ± 73 显着增加至 3,608 ± 1,841 fmol 血管紧张素 1 L/s (P< .005)，这与血浆醛固酮浓度增加七倍相关 (52 ± 12 至 402 ± 99 pg/mL，P< .001)。血浆渗透压和AVP浓度没有显着变化。结果表明，Bio-GH 诱导的钠潴留涉及肾素-血管紧张素系统的激活。这种机制可以部分解释肢端肥大症中血浆容量扩张和高血压的发生，并表明接受超生理剂量的生物 hGH 治疗身材矮小的受试者存在液体潴留和可能高血压的风险。
Previous studies using human pituitary extracts have not resolved whether the sodium retaining effects of human growth hormone (hGH) are mediated in part by increased aldosterone secretion. We have studied the effects of an authentic biosynthetic GH (bio-hGH) preparation on sodium metabolism and on the activity of the renin-angiotensin system. Six young men were administered this preparation at 0.2 U/kg/d subcutaneously for five consecutive days. Twenty-four-hour urine collections were obtained for measurement of sodium excretion and osmolality and blood collected for quantitating changes in sodium, osmolality, plasma renin activity (PRA), aldosterone, and arginine vasopressin (AVP) concentrations. Bio-hGH administration resulted in a fall in 24-hour urinary sodium excretion (197 ± 38 to 42 ± 20 mmol, mean ± SD,P< .005), a reduction in urine volume (1,652 ± 182 to 848 ± 348 mL,P< .05) but not osmolality. PRA increased significantly from 1,118 ± 73 to 3,608 ± 1,841 fmol angiotensin 1 L/s (P< .005), which was associated with a sevenfold increase in plasma aldosterone concentration (52 ± 12 to 402 ± 99 pg/mL,P< .001). Plasma osmolality and AVP concentrations did not change significantly. The results show that Bio-GH-induced retention of sodium involves the activation of the renin-angiotensin system. This mechanism may explain in part the occurrence of plasma volume expansion and hypertension in acromegaly and suggests a risk of fluid retention and possibly hypertension in subjects receiving supraphysiological doses of bio-hGH for treatment of short stature.