Predictive monitoring for early detection of subacute potentially catastrophic illnesses in critical care.
Predictive monitoring for early detection of subacute potentially catastrophic illnesses in critical care.
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DOI：
10.1109/iembs.2011.6091407
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Lake DE
中科院分区：
文献类型：
--
作者：
Moorman JR;Rusin CE;Lee H;Guin LE;Clark MT;Delos JB;Kattwinkel J;Lake DE
我们希望挽救入住ICU的患者的生命。他们的死亡率是足够高的基础上简单的原始伤害或疾病的严重性，但进一步提高了他们逗留期间的事件。我们的目标是那些亚急性但可能是灾难性的事件，如感染。例如，脓毒症是血液的细菌感染，在ICU患者中很常见，并且具有>25%的死亡风险。从逻辑上讲，早期发现和抗生素治疗应该会改善结果。我们的基本原则是，一些潜在的灾难性内科和外科疾病具有亚临床阶段，在此期间，早期诊断和治疗可能具有挽救生命的效果，这些阶段的特征是神经系统和其他器官（如心脏和肺）的正常高度复杂但高度适应性调节和相互作用的变化，临床医生和定量科学家的团队可以一起工作，以识别监测数据的临床重要异常，开发在检测异常时与临床医生的眼睛匹配的算法，并进行临床试验，以测试其对结果的影响。
We wish to save lives of patients admitted to ICUs. Their mortality is high enough based simply on the severity of the original injury or illness, but is further raised by events during their stay. We target those events that are subacute but potentially catastrophic, such as infection. Sepsis, for example, is a bacterial infection of the bloodstream, that is common in ICU patients and has a >25% risk of death. Logically, early detection and treatment with antibiotics should improve outcomes. Our fundamental precepts are some potentially catastrophic medical and surgical illnesses have subclinical phases during which early diagnosis and treatment might have life-saving effects, these phases are characterized by changes in the normal highly complex but highly adaptive regulation and interaction of the nervous system and other organs such as the heart and lungs, teams of clinicians and quantitative scientists can work together to identify clinically important abnormalities of monitoring data, to develop algorithms that match the clinicians' eye in detecting abnormalities, and to undertake the clinical trials to test their impact on outcomes.