Marginal zone and B1B cells unite in the early response against T-independent blood-borne particulate antigens
Marginal zone and B1B cells unite in the early response against T-independent blood-borne particulate antigens
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DOI：
10.1016/s1074-7613(01)00129-7
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发表时间：
2001-05-01
期刊：
影响因子：
32.4
通讯作者：
Kearney, JF
中科院分区：
文献类型：
--
作者：
Martin, F;Oliver, AM;Kearney, JF
病原体清除的速度决定了感染的程度和后果。在这种情况下，脾脏及其高度特化的淋巴区室在清除血液传播的病原体中起着核心作用。脾边缘区B细胞（MZ）由于它们的预活化状态和局部位置，在对颗粒细菌抗原的初次应答的最初3天中与B1 B细胞结合以产生大量IgM产生浆母细胞。由于这种反应的强度和速度，结合产生的抗体类型，具有“自然记忆”的脾MZ和B1 B细胞提供了非常早期的先天性和后来出现的适应性免疫反应之间的桥梁。
The rate of pathogen elimination determines the extent and consequences of an infection. In this context, the spleen with its highly specialized lymphoid compartments plays a central role in clearing blood-borne pathogens. Splenic marginal zone B cells (MZ), by virtue of their preactivated state and topographical location, join B1 B cells to generate a massive wave of IgM producing plasmablasts in the initial 3 days of a primary response to particulate bacterial antigens. Because of the intensity and rapidity of this response, combined with the types of antibodies produced, splenic MZ and B1 B cells endowed with a "natural memory" provide a bridge between the very early innate and the later appearing adaptive immune response.