Timing dysfunctions in schizophrenia span from millisecond to several-second durations
Timing dysfunctions in schizophrenia span from millisecond to several-second durations
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DOI：
10.1016/j.bandc.2009.02.001
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发表时间：
2009-07-01
影响因子：
2.5
通讯作者：
Hetrick, William P.
中科院分区：
文献类型：
--
作者：
Carroll, Christine A.;O'Donnell, Brian F.;Hetrick, William P.
精神分裂症可能与大脑中信息处理的时间协调的根本性障碍有关，导致精神分裂症的典型症状，如思维障碍和混乱和上下文不适当的行为。然而，大多数研究精神分裂症患者的时间行为的研究都采用了几秒钟的时间持续时间，这需要更高的认知过程，超出了最初的感觉登记时间编码。因此，本研究评估了毫秒和几秒的持续时间估计精神分裂症使用一个完善的任务的时间知觉。28名精神分裂症患者和31名非精神病对照组参与者完成了两项时间二分法任务，这需要参与者对听觉持续时间进行时间判断，范围从300到600毫秒或3000到6000毫秒。精神分裂症患者在毫秒和几秒的时间条件下比非精神病组表现出更大的时间变异性。这些研究结果与从时间估计的定量模型中获得的参数估计值一致，并为精神分裂症的基本时间缺陷提供了证据，该时间缺陷可能独立于待定时持续时间的长度。(C)2009 Elsevier Inc. All rights reserved.
Schizophrenia may be associated with a fundamental disturbance in the temporal coordination of information processing in the brain, leading to classic symptoms of schizophrenia such as thought disorder and disorganized and contextually inappropriate behavior. However, the majority of studies that have examined timing behavior in schizophrenia have employed temporal durations in the range of several seconds, which requires higher cognitive processes beyond initial sensory registration for temporal encoding. Accordingly, the present study assessed both millisecond and several-second duration estimates in schizophrenia using a well-established task of time perception. Twenty-eight individuals with schizophrenia and 31 non-psychiatric control participants completed two temporal bisection tasks, which required participants to make temporal judgments about auditory durations ranging from either 300 to 600 ms or 3000 to 6000 ms. Participants with schizophrenia displayed significantly greater timing variability under both millisecond and several-second timing conditions than the non-psychiatric group. These findings were consistent with parameter estimates obtained from a quantitative model of time estimation, and provide evidence for a fundamental timing deficit in schizophrenia that may be independent of the length of the to-be-timed duration. (C) 2009 Elsevier Inc. All rights reserved.