A select group of perpetrators of domestic violence: evidence of decreased metabolism in the right hypothalamus and reduced relationships between cortical/subcortical brain structures in position emission tomography
A select group of perpetrators of domestic violence: evidence of decreased metabolism in the right hypothalamus and reduced relationships between cortical/subcortical brain structures in position emission tomography
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DOI：
10.1016/s0925-4927(03)00105-7
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发表时间：
2004-01-15
影响因子：
2.3
通讯作者：
Hommer, D
中科院分区：
文献类型：
--
作者：
George, DT;Rawlings, RR;Hommer, D
在早期的一项研究中，我们报告说，一些家庭暴力的肇事者表现出夸大的恐惧相关反应的恐慌剂乳酸钠。在目前的研究中，我们采用正电子发射断层扫描（PET）来研究我们的假设，即在调解和控制家庭暴力肇事者的恐惧诱导的攻击的表达的神经结构和/或通路存在差异。对8名符合DSM-III-R酒精依赖标准（DV-ALC）的男性家庭暴力肇事者进行了局部脑葡萄糖代谢测定，11名符合DSM-III-R酒精依赖标准且无人际攻击（ALC）史的男性参与者和10名不符合任何DSM-III-R轴I诊断标准且无人际攻击史的健康男性参与者（M）。与ALC和HCS相比，DV-ALC在右侧下丘脑中的平均葡萄糖摄取显著较低。相关性的措施之间的葡萄糖利用的大脑结构参与恐惧引起的侵略。DV-ALC与HCS和ALC的比较分别在6次和7次比较中不同，涉及各种皮质和皮质下结构。左丘脑和左后眶额皮质的HCS和ALC不同。这些PET研究结果表明，一些家庭暴力的肇事者与对照组的参与者不同，他们的右下丘脑代谢较低，皮质和皮质下大脑结构之间的相关性降低。这些区域活动变化的一个可能的心理协变量可能是恐惧引起的攻击，但这一假设应该在更大的研究组中进行检查，这些研究组在成像过程中受到激发。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
In an earlier study, we reported that some perpetrators of domestic violence evidenced exaggerated fear-related responses to the panicogenic agent sodium lactate. In the current study, we employed positron emission tomography (PET) to investigate our hypothesis that there are differences in the neural structures and/or pathways that mediate and control the expression of fear-induced aggression in perpetrators of domestic violence. Regional cerebral glucose metabolism was measured in eight male perpetrators of domestic violence who fulfilled DSM-III-R criteria for alcohol dependence (DV-ALC), 11 male participants who fulfilled DSM-III-R criteria for alcohol dependence and had no history of interpersonal aggression (ALC) and 10 healthy male participants who did not fulfill criteria for any DSM-III-R axis I diagnosis and had no history of interpersonal aggression (M). DV-ALC had a significantly lower mean glucose uptake in the right hypothalamus compared to ALC and HCS. Correlations were performed between measures of glucose utilization in the brain structures involved in fear-induced aggression. The comparison of DV-ALC to HCS and to ALC differed in six and seven comparisons, respectively, involving various cortical and subcortical structures. HCS and ALC differed between the left thalamus and the left posterior orbitofrontal cortex. These PET findings show that some perpetrators of domestic violence differ from control participants in showing lower metabolism in the right hypothalamus and decreased correlations between cortical and subcortical brain structures. A possible psychological covariate of these changes in regional activity might be fear-induced aggression, but this hypothesis should be examined in larger study groups that undergo provocation during imaging. (C) 2003 Elsevier Ireland Ltd. All rights reserved.