SUPEROXIDE-DISMUTASE, GLUTATHIONE-PEROXIDASE, CATALASE AND LIPID-PEROXIDATION OF NORMAL AND SICKLED ERYTHROCYTES
SUPEROXIDE-DISMUTASE, GLUTATHIONE-PEROXIDASE, CATALASE AND LIPID-PEROXIDATION OF NORMAL AND SICKLED ERYTHROCYTES
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DOI：
10.1111/j.1365-2141.1980.tb01186.x
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发表时间：
1980-01-01
影响因子：
6.5
通讯作者：
NAIR, RC
中科院分区：
文献类型：
--
作者：
DAS, SK;NAIR, RC
与正常红细胞相比，镰刀状红细胞的谷胱甘肽过氧化物酶和过氧化氢酶活性降低。在镰状红细胞中发现超氧化物歧化酶和过氧化电位的水平以及提示膜脂过氧化的荧光脂色素和丙二醛的水平增加。镰刀状红细胞可见膜结合的亨氏小体，膜脂减少，不饱和脂肪酸减少。镰状细胞明显发生膜脂过氧化。
Sickled erythrocytes showed reduced glutathione peroxidase and catalase activities in comparison to normal erythrocytes. Increased levels of superoxide dismutase and peroxidation potential as well as fluorescent lipid pigments and malonaldehyde suggestive of membrane lipid peroxidation were found in sickled erythrocytes. Sickled erythrocytes showed membrane bound Heinz bodies, reduced membrane lipids and unsaturated fatty acids. Membrane lipid peroxidation apparently occurs in sickled cells.