Comparison of the composition of faecal fluid in Crohn's disease and ulcerative colitis.
Comparison of the composition of faecal fluid in Crohn's disease and ulcerative colitis.
复制标题
克罗恩病和溃疡性结肠炎粪便液成分的比较。
作者：
R. Schilli;R. I. Breuer;F. Klein;K. Dunn;A. Gnaedinger;J. Bernstein;M. Paige;M. Kaufman
我们测定了13例局限于结肠的克罗恩病患者、10例弥漫性溃疡性结肠炎患者和8例溃疡性直肠炎患者的粪便离子成分。克罗恩病组和结肠炎组的结肠表面受累程度相似，24小时粪便重量相似。然而，克罗恩病患者的粪液具有算术上较低的平均钠和统计上较低的平均氯(34.8mmoL/L+/-16.2SD比53.1mmol/L+/-23.1SD)和更高的钾(49.2mmol/L+/-20.2SD比33.0mmol/L+/-13.8SD)浓度(p<0.05)和高得多的渗透压(487.1 mOmol/kg+/-87.1SD比341.1 mOmol/kg+/-88.9SD)，P<0.001)。使用粪便渗透间隙对这些患者进行分离，86%的病例符合临床分类。直肠炎患者的腹泻具有接近正常的离子成分，这与弥漫性结肠炎的腹泻明显不同。这些结果提示克罗恩腹泻和溃疡性结肠炎的组成和可能的发病机制不同。液体成分可能被证明是一种有用的、非侵入性的方法，用于对炎症性肠病患者进行分类，并在溃疡性结肠炎中确定炎症过程的程度。
We determined the ionic composition of faecal fluid from 13 patients with Crohn's disease limited to the colon, 10 with diffuse ulcerative colitis, and eight with ulcerative proctitis. The Crohn's and colitis groups had similar proportions of colon surface involved radiographically and similar 24 hour faecal weights. However, Crohn's patients' faecal fluid had arithmetically lower mean sodium and statistically lower mean chloride (34.8 mmol/l +/- 16.2 SD vs. 53.1 mmol/l +/- 23.1 SD) and higher potassium (49.2 mmol/l +/- 20.2 SD vs. 33.0 mmol/l +/- 13.8 SD) concentrations (p less than 0.05 for each) and much higher osmolality (487.1 mOsmol/kg +/- 87.1 SD vs. 341.1 mOsmol/kg +/- 88.9 SD, p less than 0.001). Separation of these patients using the faecal osmotic gap agreed with the clinical classification in 86% of cases. The diarrhoea of proctitis patients had a nearly normal ionic composition which was clearly distinguishable from that of diffuse colitis. These results suggest differences in the composition and perhaps the pathogenesis of the diarrhoea of Crohn's and ulcerative colitis. The composition of fluid may prove a useful, non-invasive method for classifying patients with inflammatory bowel disease and, in ulcerative colitis, determining the extent of the inflammatory process.