Three-dimensional reconstruction of blood vessels from in vivo color Doppler optical coherence tomography images
Three-dimensional reconstruction of blood vessels from in vivo color Doppler optical coherence tomography images
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DOI：
10.1159/000018148
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发表时间：
1999-01-01
期刊：
影响因子：
3.4
通讯作者：
Welch, AJ
中科院分区：
文献类型：
--
作者：
Barton, JK;Izatt, JA;Welch, AJ
目的：目前的激光治疗血管疾病，如葡萄酒色斑可能有不完整或不可接受的结果。基于患者血管结构的知识的定制治疗策略可以实现改善的临床结果。程序：本研究应用彩色多普勒光学相干断层扫描（OCT）和图像处理技术对大鼠和仓鼠皮肤血管进行定位、测量和重建。光学相干断层扫描是一种新的，潜在的非侵入性技术，用于成像亚表面组织结构与微米尺度的分辨率。结果：在一系列断层图像中识别出血管，并进行三维重建。从图像中发现了可能影响最佳激光治疗参数的参数，例如平均血管深度和管腔直径。结论：本研究表明，彩色多普勒OCT是改善血管疾病激光治疗的潜在工具。
Purpose: Current laser treatment for vascular disorders such as port wine stains can have incomplete or unacceptable results. A customized treatment strategy based on knowledge of the patient's blood vessel structure may effect an improved clinical outcome. Procedure: We tested the feasibility of using color Doppler optical coherence tomography (OCT) and image processing techniques to locate, measure and reconstruct cutaneous blood vessels in rat and hamster skin. OCT is a recent, potentially noninvasive technique for imaging subsurface tissue structures with micrometer scale resolution. Results: Blood vessels were identified in a series of cross-sectional images, then a three-dimensional reconstruction was made. Parameters that can affect optimum laser treatment parameters, such as average blood vessel depth and luminal diameter, were found from the images. Conclusion: This study shows that color Doppler OCT is a potential tool for improving laser treatment of vascular disorders.