Mapping the growth hormone--Stat5b--IGF-I transcriptional circuit.
Mapping the growth hormone--Stat5b--IGF-I transcriptional circuit.
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DOI：
10.1016/j.tem.2012.01.001
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发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Rotwein P
中科院分区：
文献类型：
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作者：
Rotwein P
生长激素（GH）和胰岛素样生长因子-I（IGF-I）对机体的生长、代谢和组织修复产生强大的影响，并与衰老和癌症发生有关。自50多年前生长调节素假说提出以来，GH和IGF-I一直密切相关。最近的研究已经确定，GH有效地刺激IGF-I基因转录，并通过这种机制控制IGF-I的产生。GH-IGF-I生物合成途径的关键介质是潜在转录因子Stat 5 b。这篇综述总结了潜在的复杂的机制之间的关系GH的行动，Stat 5 b，IGF-I基因激活，并建议Stat 5 b可能有广泛的作用，在介导IGF-I基因调节响应于不同的生理输入。
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) exert powerful influences on somatic growth, metabolism, and tissue repair, and have been implicated in aging and carcinogenesis. Since the formulation of the somatomedin hypothesis over 50 years ago, GH and IGF-I have been linked intimately to one another. Recent studies have established that GH potently stimulates IGF-I gene transcription, and through this mechanism controls production of IGF-I. A key mediator of the GH - IGF-I biosynthetic pathway is the latent transcription factor Stat5b. This review summarizes the potentially complex mechanistic relationship among GH action, Stat5b, and IGF-I gene activation, and suggests that Stat5b may have a broad role in mediating IGF-I gene regulation in response to diverse physiological inputs.