Molecular epidemiology of HIV type 1 subtypes in Taiwan: Outbreak of HIV type 1 CRF07_ BC infection in intravenous drug users
Molecular epidemiology of HIV type 1 subtypes in Taiwan: Outbreak of HIV type 1 CRF07_ BC infection in intravenous drug users
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DOI：
10.1089/aid.2006.22.1055
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发表时间：
2006-11-01
影响因子：
1.5
通讯作者：
Chang, Shan-Chwen
中科院分区：
文献类型：
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作者：
Chang, Sui-Yuan;Sheng, Wang-Huei;Chang, Shan-Chwen
在台湾，性传播是大多数HIV-1感染的原因，主要有两种亚型，亚型B和CRF 01_AE，分别分布在同性恋和异性恋群体中。最近，静脉注射吸毒已成为艾滋病毒-1传播的一个新途径，并导致艾滋病毒-1感染的显著增加。为了解造成静脉注射毒品者（IDUs）爆发的HIV分离株的特征，对台大医院和台北市性病防治中心HIV-1感染者的蛋白酶/RT序列进行系统发育分析。CRF07_BC是在中国北方流行的一种HIV-1病毒，在过去的2年中被证明是注射吸毒者中HIV-1感染的主要原因。尽管这些台湾CRF07_BC序列与CRF07_BC参考序列中描述的断点位置相同，但它们在系统发育树中形成了独特的簇，表明它们起源于创始病毒。这一发现进一步得到了相对较低的遗传多样性和独特的序列特征的支持。我们的研究结果显示CRF07_BC的出现及其与2004年至2005年台湾注射吸毒者中HIV-1爆发的相关性。这一发现不仅有助于我们更好地了解亚洲艾滋病毒的演变，而且对未来的疫苗设计具有重要意义。
In Taiwan, sexual transmission is responsible for most HIV-1 infections with two dominant subtypes, subtype B and CRF01_AE, distributing among homosexual and heterosexual groups, respectively. Recently, intravenous drug use has become an emerging route of HIV-1 transmission and contributed to a significant increase of HIV-1 infection. To characterize the HIV isolates responsible for the outbreak among intravenous drug users (IDUs), phylogenetic analysis was performed to analyze the protease/RT sequences amplified from HIV-1-infected IDUs at National Taiwan University Hospital and Taipei City STD Control Center. CRF07_BC, which is circulating in northern China, was demonstrated to account for the majority of HIV-1 infection in IDUs in the past 2 years. Although these Taiwanese CRF07_BC sequences shared the same breakpoint positions as those described in the CRF07_BC reference sequences, they formed a unique cluster in the phylogenetic tree, suggesting they originated from a founder virus. This finding was further supported by the relative low genetic diversity and unique sequence features. Our results demonstrated the emergence of CRF07_BC and its association with the HIV-1 outbreak among IDUs between 2004 and 2005 in Taiwan. This finding not only helps us to have a better understanding of the HIV evolution in Asia, but also has important implications for vaccine design in the future.