Unconscious amygdalar fear conditioning in a subset of chronic fatigue syndrome patients
Unconscious amygdalar fear conditioning in a subset of chronic fatigue syndrome patients
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DOI：
10.1016/s0306-9877(02)00321-3
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发表时间：
2002-12-01
影响因子：
4.7
通讯作者：
Gupta, A
中科院分区：
文献类型：
--
作者：
Gupta, A
在这里，一个新的假说慢性疲劳综合征（CFS）的建议。CFS可能是一种集中在杏仁核的神经生理学障碍。在“创伤性”神经事件中，通常涉及急性心理应激与病毒感染或其他化学或生理应激源的结合，杏仁核中可能会产生条件网络或“细胞组装”。无意识的杏仁核可能会对身体产生的负面症状长期敏感。来自内脏或生理、化学和饮食应激源的负面信号成为条件刺激，条件反应是杏仁核通过包括下丘脑在内的各种大脑通路的慢性交感神经流出。这种细胞组装然后产生CFS恶性循环，其中对症状的无意识负面反应导致免疫再激活/功能障碍，慢性交感神经刺激，导致交感神经功能障碍，精神和身体疲惫，以及一系列其他令人痛苦的症状和继发性并发症。而这些正是杏仁核和相关的边缘结构被训练来监测和应对的症状，使恶性循环持续下去。CFS的恢复可能涉及内侧前额叶皮质向杏仁核的投射，以控制杏仁核的expressions.I将首先讨论慢性疲劳综合征（CFS）的可能病因学中涉及的诱发因素、促发因素和持续因素，然后是患者的疾病经历。最后，我将看看对CFS症状的解释。(C)2002爱思唯尔科技有限公司。保留所有权利。
Here, a novel hypothesis for chronic fatigue syndrome (CFS) is proposed. CFS may be a neurophysiological disorder focussing on the amygdala. During a 'traumatic' neurological event often involving acute psychological stress combined with a viral infection or other chemical or physiological stressor, a conditioned network or 'cell assembly' may be created in the amygdala. The unconscious amygdala may become conditioned to be chronically sensitised to negative symptoms arising from the body. Negative signals from the viscera or physiological, chemical and dietary stressors, become conditioned stimuli and the conditioned response is a chronic sympathetic outpouring from the amygdala via various brain pathways including the hypothalamus.This cell assembly then produces the CFS vicious circle, where an unconscious negative reaction to symptoms causes immune reactivation/dysfunction, chronic sympathetic stimulation, leading to sympathetic dysfunction, mental and physical exhaustion, and a host of other distressing symptoms and secondary complications. And these are exactly the symptoms that the amygdala and associated limbic structures are trained to monitor and respond to, perpetuating a vicious circle. Recovery from CFS may involve projections from the medial prefrontal cortex to the amygdala, to control the amygdala's expressions.I shall firstly discuss predisposing, precipitating, and perpetuating factors involved in the possible etiology of chronic fatigue syndrome (CFS), followed by the patient's experience of the illness. Finally, I shall look at a suggested explanation for the symptoms of CFS. (C) 2002 Elsevier Science Ltd. All rights reserved.