Serial assessment of sympathetic reinnervation after orthotopic heart transplantation - A longitudinal study using PET and C-11 hydroxyephedrine
Serial assessment of sympathetic reinnervation after orthotopic heart transplantation - A longitudinal study using PET and C-11 hydroxyephedrine
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DOI：
10.1161/01.cir.99.14.1866
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发表时间：
1999-04-13
期刊：
影响因子：
37.8
通讯作者：
Schwaiger, M
中科院分区：
文献类型：
--
作者：
Bengel, FM;Ueberfuhr, P;Schwaiger, M
背景-心脏移植（HTX）后晚期交感神经再支配的进展性知之甚少。本研究的目的是描述HTX后的交感神经末梢的纵向定量assessment.Methods和Results-In 20例HTX后，动态PET与C-11羟麻黄碱（HED）进行了两次在3.0+/-0.5年内的个人成长。根据HTX与首次PET检查的时间间隔，确定HTX后早期（A组，7年; n=6）的患者亚组。在首次HED PET时，10例患者完全失神经支配（A组7例，B组2例，C组1例）。第二次PET时，仅3例仍失神经支配。在第一次和第二次PET之间，所有3组均发现再神经支配心肌显著增加（A组为0%至9+/-9%，P
Background-Little is known about the progressiveness of sympathetic reinnervation late after cardiac transplantation (HTX). The aim of the present study was to describe individual growth of sympathetic terminals after HTX by a longitudinal quantitative assessment.Methods and Results-In 20 patients after HTX, dynamic PET with C-ll hydroxyephedrine (HED) was performed twice within 3.0+/-0.5 years. According to the time interval between HTX and first PET, subgroups of patients early (group A, 7 years; n=6) after HTX were defined. At the time of first HED PET, 10 patients were completely denervated (7 in group A, 2 in group B, and 1 in group C). Only 3 remained denervated at second PET. A significant increase of reinnervated myocardium between first and second PET was found in all 3 groups (0% to 9+/-9% of left ventricle for group A, P