MicroRNA responses to environmental liver carcinogens: Biological and clinical significance.
MicroRNA responses to environmental liver carcinogens: Biological and clinical significance.
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DOI：
10.1016/j.cca.2015.03.006
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发表时间：
2015-05
期刊：
影响因子：
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通讯作者：
V. Nicolaidou;C. Koufaris
中科院分区：
文献类型：
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作者：
V. Nicolaidou;C. Koufaris
大量的生物、化学和饮食因素与肝癌的发展有关。这些涉及遗传、表观遗传和环境因素之间复杂而持久的相互作用。由于疾病的侵袭性和对治疗的抵抗性，诊断为晚期肝癌的患者的存活率目前很低。越来越多的证据支持非编码microRNA（miRNA）在指导肝脏对肝癌环境风险因素的反应中的关键作用。本文就miRNA对环境肝癌危险因素的反应及其潜在的生物学和临床意义作一综述。
A large number of biological, chemical, and dietary factors have been implicated in the development of liver cancer. These involve complex and protracted interactions between genetic, epigenetic, and environmental factors. The survival rate for patients diagnosed with late-stage liver cancer is currently low due to the aggressive nature of the disease and resistance to therapy. An increasing body of evidence has offered support for the crucial role of non-coding microRNA (miRNA) in directing hepatic responses to environmental risk factors for liver cancer. In this review we focus on miRNA responses to environmental liver cancer risk factors and their potential biological and clinical significance.