Association of coronary risk factors with progression of valvular aortic stenosis in older persons
Association of coronary risk factors with progression of valvular aortic stenosis in older persons
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DOI：
10.1016/s0002-9149(01)01531-4
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发表时间：
2001-06-01
影响因子：
2.8
通讯作者：
Goldman, ME
中科院分区：
文献类型：
--
作者：
Nassimiha, D;Aronow, WS;Goldman, ME
本研究中的多元线性回归分析显示，老年人瓣膜AS进展的显著独立风险因素为吸烟（p = 0.0001）和高胆固醇血症（p = 0.0001），糖尿病显示临界显著性（p 0.0581）。Palta等人（16）最近报道，吸烟和高胆固醇血症加速AS的进展。他们的数据和我们的数据表明，应该进行一项研究，以调查降低血清低密度脂蛋白胆固醇对瓣膜AS进展速度的影响。
Multiple linear regression analysis in the present study showed that significant independent risk factors for progression of valvular AS in older persons were cigarette smoking (p = 0.0001) and hypercholesterolemia (p = 0.0001), with diabetes mellitus showing borderline significance (p 0.0581). Palta et al(16) recently reported that cigarette smoking and hypercholesterolemia accelerate the progression of AS. Their data and our data suggest that a study should be performed to investigate the effect of lowering serum Low-density lipoprotein cholesterol on the rate of progression of valvular AS.