Collecting Duct Intercalated Cell Function and Regulation
Collecting Duct Intercalated Cell Function and Regulation
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DOI：
10.2215/cjn.08880914
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发表时间：
2015-02-01
影响因子：
9.8
通讯作者：
Pastor-Soler, Nuria M.
中科院分区：
文献类型：
--
作者：
Roy, Ankita;Al-bataineh, Mohammad M.;Pastor-Soler, Nuria M.
插层细胞是肾小管上皮细胞，在调节机体酸碱平衡中起重要作用。然而，近年来，对嵌入细胞功能的理解已经大大增强，并形成了肾小管远端部分如何整合盐和水的重吸收、钾稳态和酸碱状态的新模型。这些细胞出现在远曲小管晚期或连接段，这取决于物种。它们在集合管中最为丰富，从皮层到内髓质的初始部分都可以检测到它们。插层细胞散布在更多的节段特异性主细胞中。有三种类型的插层细胞，每一种都有不同的结构，表达不同的运输蛋白集合，这些蛋白质在尿液处理过程中转化为非常不同的功能。本文综述了嵌入细胞如何调节其细胞内环境，促进酸碱调节和钠、氯、钾稳态的最新发现，从而强调了它们作为高血压治疗靶点的潜在作用。本文还讨论了收集管中旁分泌信号对它们的新调控。最后，本文讨论了它们作为肾小管先天免疫系统的一部分的作用。
Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of acid-base homeostasis. However, in recent years the understanding of the function of the intercalated cell has become greatly enhanced and has shaped a new model for how the distal segments of the kidney tubule integrate salt and water reabsorption, potassium homeostasis, and acid-base status. These cells appear in the late distal convoluted tubule or in the connecting segment, depending on the species. They are most abundant in the collecting duct, where they can be detected all the way from the cortex to the initial part of the inner medulla. Intercalated cells are interspersed among the more numerous segment-specific principal cells. There are three types of intercalated cells, each having distinct structures and expressing different ensembles of transport proteins that translate into very different functions in the processing of the urine. This review includes recent findings on how intercalated cells regulate their intracellular milieu and contribute to acid-base regulation and sodium, chloride, and potassium homeostasis, thus highlighting their potential role as targets for the treatment of hypertension. Their novel regulation by paracrine signals in the collecting duct is also discussed. Finally, this article addresses their role as part of the innate immune system of the kidney tubule.