A role for local calcium signaling in rapid synaptic partner selection by dendritic filopodia
A role for local calcium signaling in rapid synaptic partner selection by dendritic filopodia
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DOI：
10.1016/j.neuron.2008.05.025
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发表时间：
2008-07-31
期刊：
影响因子：
16.2
通讯作者：
Bonhoeffer, Tobias
中科院分区：
文献类型：
--
作者：
Lohmann, Christian;Bonhoeffer, Tobias
突触消除是发育过程中功能性神经元网络建立的重要基础过程。在这里，我们测试的想法，神经元之间选择潜在的突触伙伴已经在最初的接触形成树突状丝状伪足和轴突之间的成熟突触建立之前。我们发现，丝状伪足经常与轴突接触，而一些接触是选择性稳定的，许多是短暂的。更具体地说，我们证明了与一定数量的GABA能轴突的接触永远不会稳定，这表明丝状伪足已经在早期选择不同类型的轴突。局部树突状钙瞬变，是独立的谷氨酸发生在接触形成后几秒钟内，其频率是高的接触变得稳定和低，在短暂的接触。因此，丝状伪足能够在成熟的突触建立之前就在潜在的突触伴侣之间进行选择。
Synapse elimination is an important process underlying the establishment of functional neuronal networks during development. Here, we tested the idea that neurons select among potential synaptic partners already during initial contact formation between dendritic filopodia and axons-well before mature synapses are established. We show that filopodia frequently make contact with axons, and while some contacts are selectively stabilized, many are short-lived. More specifically, we demonstrate that contacts with a certain population of GABAergic axons never get stabilized, indicating that filopodia already early on select between different types of axons. Local dendritic calcium transients that are independent of glutamate occur within seconds after contact formation, and their frequency is high where contacts become stabilized and low at short-lived contacts. Thus, filopodia are capable of choosing between potential synaptic partners well before a mature synapse is established.