GABA-induced inactivation of dorsal midline thalamic subregions has distinct effects on emotional behaviors.
GABA-induced inactivation of dorsal midline thalamic subregions has distinct effects on emotional behaviors.
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DOI：
10.1016/j.neulet.2015.10.029
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发表时间：
2015-11-16
影响因子：
2.5
通讯作者：
Leibowitz SF
中科院分区：
文献类型：
--
作者：
Barson JR;Leibowitz SF
丘脑室旁核（PVT）是整合情绪信息并将输出传递给影响运动行为的其他边缘结构的关键节点。最近的研究表明，该核的前亚区（aPVT）和后亚区（pPVT）在摄取行为中具有不同的解剖连接和功能，本研究探讨了它们是否对情绪行为也有不同的贡献。在aPVT或pPVT中微量注射生理盐水或GABAB+GABAA激动剂巴氯芬+muscimol (bac+mus; 0.3+0.03 nmol)，以抑制神经活动，然后测试受试者之间情绪行为的差异。在一个新的活动室中，bac+mus显著降低了运动活动，在pPVT注射后这种变化比aPVT注射后更大。在一个熟悉的活动室中，bac+mus再次降低运动活动，但在aPVT和pPVT注射后引起类似的变化。在升高+迷宫中，bac+mus显著减少了张开臂时间和进入次数，尽管这仅在pPVT注射后观察到。因此，虽然两个PVT亚区都是一般运动活动所必需的，但pPVT似乎在新奇诱导的活动和焦虑样行为中都有更大的功能，这表明该亚区比aPVT对应激刺激的反应有更大的贡献。
The paraventricular nucleus of the thalamus (PVT) is a key node integrating information about emotion and relaying output to other limbic structures influencing motor behavior. With recent studies showing the anterior (aPVT) and posterior (pPVT) subregions of this nucleus to have different anatomical connections and functions in ingestive behavior, the present study investigated whether they also make different contributions to emotional behaviors. Rats were microinjected in the aPVT or pPVT with saline vehicle or the GABAB+GABAA agonists, baclofen+muscimol (bac+mus; 0.3+0.03 nmol), to inhibit neural activity and were then tested between-subject for differences in emotional behavior. In a novel activity chamber, bac+mus significantly reduced locomotor activity, with this change somewhat larger after injection in the pPVT than the aPVT. In a familiar activity chamber, bac+mus again reduced locomotor activity but induced similar changes after injection in the aPVT and pPVT. In an elevated plus maze, bac+mus significantly decreased open arm time and entries, although this was observed only after injection in the pPVT. Thus, while both PVT subregions are necessary for general locomotor activity, the pPVT appears to have a greater function in both novelty-induced activity and anxiety-like behavior, indicating that this subregion makes a greater contribution than the aPVT to reactions to stressful stimuli.