A Perspective on Cirrhotic Cardiomyopathy
A Perspective on Cirrhotic Cardiomyopathy
复制标题
DOI：
10.1016/j.transproceed.2011.01.188
复制
发表时间：
2011-06-01
影响因子：
0.9
通讯作者：
Vittorio, T. J.
中科院分区：
文献类型：
--
作者：
Timoh, T.;Protano, M. A.;Vittorio, T. J.
肝硬化患者的心功能障碍和潜在的临床意义早已为人所知，但病理生理学和治疗干预的潜在靶点仍在研究中，现在才开始了解。病理生理变化导致收缩功能障碍、舒张功能障碍和电生理变化。在这里，我们的目的是从细胞和生理模型，以及这些患者如何发展明显的心力衰竭的压力设置，如感染，腹水，和程序，包括经颈静脉肝内门体分流，门腔静脉分流，原位肝移植。我们还将审查最新的，但有限的，可用的治疗方式。
Cardiac dysfunction in patients with cirrhosis and potential clinical implications have long been known, but the pathophysiology and potential targets for therapeutic intervention are still under investigation and are only now becoming understood. The pathophysiological changes result in systolic dysfunction, diastolic dysfunction, and electrophysiological changes. Here, we aim to review cirrhotic cardiomyopathy from a cellular and physiological model and how these patients develop overt heart failure in the setting of stress, such as infection, ascites, and procedures including transjugular intrahepatic portosystemic shunt, portocaval shunts, and orthotopic liver transplantation. We will also review the most current, although limited, available therapeutic modalities.