IMPAIRMENT BY APOMORPHINE OF ONE-TRIAL PASSIVE-AVOIDANCE LEARNING IN MICE - OPPOSING ROLES OF THE DOPAMINE AND NORADRENALINE SYSTEMS
IMPAIRMENT BY APOMORPHINE OF ONE-TRIAL PASSIVE-AVOIDANCE LEARNING IN MICE - OPPOSING ROLES OF THE DOPAMINE AND NORADRENALINE SYSTEMS
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DOI：
10.1007/bf00426809
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发表时间：
1979-01-01
影响因子：
3.4
通讯作者：
DELRIO, J
中科院分区：
文献类型：
--
作者：
FERNANDEZTOME, MP;SANCHEZBLAZQUEZ, P;DELRIO, J
训练前给予多巴胺能兴奋剂阿扑吗啡（0.25-16 mg/kg）损害了小鼠在一次试验被动回避任务中的保持能力。只有在非常高剂量（16 mg/kg）的这种药物的作用似乎与干扰记忆形成过程有关。在使用的多巴胺受体阻断剂中，氟哌啶醇（0.125-1 mg/kg），而不是氯丙嗪或氯氮平（0.25-4 mg/kg），阻止了阿扑吗啡效应。酚苄明（8毫克/公斤），去甲肾上腺素[去甲肾上腺素]受体阻滞剂，拮抗氟哌啶醇的作用，当与亚有效剂量的阿扑吗啡，受损的被动回避学习。所获得的结果解释在中央去甲肾上腺素对多巴胺系统的大脑所施加的拟议的抑制作用。
Pretraining administration of the dopaminergic stimulant apomorphine (0.25-16 mg/kg) impaired retention performance of mice on a one-trial passive avoidance task. Only with a very high dose (16 mg/kg) of this drug did the effect seem related to an interference with memory formation processes. Of the dopamine receptor-blocking agents used, haloperidol (0.125-1 mg/kg), but not chlorpromazine or clozapine (0.25-4 mg/kg), prevented the apomorphine effect. Phenoxybenzamine (8 mg/kg), a noradrenaline [norepinephrine] receptor-blocker, antagonized the haloperidol effect and, when combined with a subeffective dose of apomorphine, impaired passive avoidance learning. The results obtained are interpreted in terms of the proposed inhibitory actions exerted by central noradrenaline on dopamine systems of the brain.