Mechanical factors influencing collateral ventilation in human, dog, and pig lungs.
Mechanical factors influencing collateral ventilation in human, dog, and pig lungs.
复制标题
影响人、狗和猪肺侧支通气的机械因素。
DOI：
10.1152/jappl.1971.30.1.99
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发表时间：
1971
影响因子：
3.3
通讯作者：
P. Macklem
中科院分区：
文献类型：
--
作者：
A. Woolcock;P. Macklem
Woolcock，Ann J”，AND Peter T.麦克伦。影响人、狗和猪肺侧支通气的机械因素。J.Appl.Physiol.30（1）：99- 115。1971.--用两种方法测定了人、狗和猪肺在不同生理条件下的侧支通气时间常数（T），结果具有可比性。T值与犬和人的整个肺的值顺序相同;它们随年龄、肺体积、体积史、侧支通气空间体积、支气管张力以及肺是否切除或原位而变化。侧支通道的流动阻力和侧支通气空间的顺应性的相对值在确定这些变量如何影响这些物种的侧支通气中是重要的。无法确定猪肺中是否存在侧支通气。由于在狗和人的肺中，空气可以像通过气道一样快速地通过侧支通道流入肺实质，因此在确定气道阻塞时发生的功能异常的程度时，任何给定肺中存在的侧支通气的程度将是重要的。时间常数物种差异;肺的机械性质货车艾伦、林斯科格和里希特（23）在1931年的经典研究表明，在某些物种中，即使通向肺实质部分的气道完全闭塞，空气也可以通过侧支通道进入肺实质。Lindskog和Bradshaw（13）估计，在犬中，通过侧支通道输送至气道阻塞节段的潮气量至少为气道通畅且该节段正常通气时潮气量的10 72。
WOOLCOCK, ANN J”, AND PETER T. MACKLEM. Mechanicalfactors injkencing collateral ventilation in human, dog, and pig lungs. J. Appl. Physiol. 30 (l): 99-l 15. 1971.--The time constant(T) for collateral ventilation was measured in human, dog, and pig lungs under different physiological conditions by two methods with comparable results. Values for T were of the same order as values for the whole lungs in the dog and human; they varied with age, lung volume, volume history, volume of the collaterally ventilated space, bronchomotor tone, and whether the lungs were excised or in situ. The relative values of the flow resistance of the collateral channels and the compliance of the collaterally ventilated space were important in determining how these variables influenced collateral ventilation in these species. It was not possible to be sure that collateral ventilation exists in the pig lung. Since in the dog and human lungs it is possible for air to flow into the parenchyma just as quickly through collateral channels as it does through airways, the degree of collateral ventilation present in any given lung will be important in determining the degree of functional abnormality occurring in response to airway obstruction. time constant; species differences; mechanical properties of lungsTHE CLASSIC STUDIES of Van Allen, Lindskog, and Richter (23) in 193 1 established that in some species air may enter the parenchyma of lung through collateral channels, even though the airway leading to that part of the parenchyma is completely occluded. Lindskog and Bradshaw(13) estimated that in the dog the tidal volume delivered through collateral channels to a segment the airways of which were occluded was at least 10 72 of the tidal volume when the airway was unobstructed and the segment was ventilated normally.