Preparation of biocompatible nano-ZnO/Chitosan microspheres with multi-functions of antibacterial, UV-shielding and dye photodegradation.
Preparation of biocompatible nano-ZnO/Chitosan microspheres with multi-functions of antibacterial, UV-shielding and dye photodegradation.
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DOI：
10.1016/j.ijbiomac.2019.09.217
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发表时间：
2019-11
影响因子：
8.2
通讯作者：
Ru Zhong;Quan Zhong;Meijun Huo;Binglin Yang;Hong Li
中科院分区：
文献类型：
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作者：
Ru Zhong;Quan Zhong;Meijun Huo;Binglin Yang;Hong Li
纳米氧化锌（nZnO）作为抗菌、防紫外线和抗紫外线材料已得到广泛应用，但其生物安全性存在争议。本文介绍了壳聚糖（CS）的引入，以提高生物相容性。为了解决纳米ZnO与CS酸溶液反应的问题，采用交替进料喷雾干燥法制备了纳米ZnO/CS复合微球。结果表明，纳米ZnO保持六方晶相，分散嵌入CS微球中。根据细胞毒性和溶血试验结果，生物安全性明显提高。此外，nZnO/CS的抗菌活性明显优于CS和nZnO。评价了其紫外屏蔽性能和光催化降解性能。总之，交替进料喷雾干燥法是一种制备多功能纳米ZnO/CS微球的新方法，具有成本低、生物安全性好等优点。
Nano-ZnO (nZnO) has been widely used as antibacterial, UV-shielding and photocatalysis materials, but limited by its contentious biosafety. In this paper, chitosan (CS) was introduced to enhance the biocompatibility. To solve the problem that nZnO reacts with the CS acid solution, alternate-feed spray drying was adopted to fabricate nZnO/CS composite microspheres. It was showed that nZnO remained the hexagonal phase, dispersed and embedded into CS microspheres. Based on the results of cytotoxicity and hemolysis test, biosafety was improved obviously. Further, the antibacterial activity of nZnO/CS was notably better than either of CS and nZnO individually. UV-shielding property and photocatalytic degradation test were estimated. In a word, alternate-feed spray drying presents a novel and cost-efficient method to fabricate multifunctional nZnO/CS microspheres with enhanced biosafety.