Reversible Encephalopathy Syndrome (PRES) in a COVID-19 patient
Reversible Encephalopathy Syndrome (PRES) in a COVID-19 patient
复制标题
DOI：
10.1007/s00415-020-10001-7
复制
发表时间：
2020-06-24
影响因子：
6
通讯作者：
Versino, Maurizio
中科院分区：
文献类型：
--
作者：
Cariddi, Lucia Princiotta;Damavandi, Payam Tabaee;Versino, Maurizio
最近，世界卫生组织宣布 2019 年新型冠状病毒病（COVID-19）爆发为大流行病。急性呼吸综合征似乎是 COVID-19 最常见的表现。除肺炎外，已证明SARS-CoV-2感染会影响包括脑组织在内的多个器官，引起不同的神经系统表现，特别是急性脑血管疾病（缺血性和出血性中风）、意识障碍和骨骼肌损伤。据我们所知，在与 SARS-CoV2 感染相关的神经系统疾病中，尚未描述可逆性后部脑病综合征 (PRES)。在此，我们报告了一名 64 岁女性感染 COVID19 后出现 PRES 的病例，我们认为这可能是由于 SARS-CoV-2 引起的脑血管内皮功能障碍导致血脑屏障破坏所致。
Recently WHO has declared novel coronavirus disease 2019 (COVID-19) outbreak a pandemic. Acute respiratory syndrome seems to be the most common manifestation of COVID-19. Besides pneumonia, it has been demonstrated that SARS-CoV-2 infection affects multiple organs, including brain tissues, causing different neurological manifestations, especially acute cerebrovascular disease (ischemic and hemorrhagic stroke), impaired consciousness and skeletal muscle injury. To our knowledge, among neurological disorders associated with SARS-CoV2 infection, no Posterior Reversible Encephalopathy Syndrome (PRES) has been described yet. Herein, we report a case of a 64-year old woman with COVID19 infection who developed a PRES, and we suggest that it could be explained by the disruption of the blood brain barrier induced by the cerebrovascular endothelial dysfunction caused by SARS-CoV-2.