High-Affinity Disaccharide Binding by Tricyclic Synthetic Lectins
High-Affinity Disaccharide Binding by Tricyclic Synthetic Lectins
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DOI：
10.1002/anie.201200447
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发表时间：
2012-01-01
影响因子：
16.6
通讯作者：
Davis, Anthony P.
中科院分区：
文献类型：
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作者：
Sookcharoenpinyo, Bunyarithi;Klein, Emmanuel;Davis, Anthony P.
严格的预组织并不总是分子识别的最佳方法。与以前的合成凝集素不同，新的受体（见图）被合成，具有构象自由，允许疏水驱动的腔塌陷。尽管如此，它们在水中结合碳水化合物目标具有开创性的亲和力（甲基纤维素生物苷高达4500 M−1，R= Me）和选择性。
Rigid preorganization is not always the best approach to molecular recognition. Unlike previous synthetic lectins, new receptors (see picture) were synthesized that possess conformational freedom which allows hydrophobically driven collapse of the cavity. Nonetheless, they bind their carbohydrate targets in water with ground-breaking affinities (up to 4500 M− 1 for methyl cellobioside, R= Me) and selectivities.