Effects of pubertal development, height, weight, and grip strength on the bone mineral density of the lumbar spine and hip in peripubertal Japanese children: Kyoto kids increase density in the skeleton study (Kyoto KIDS study)
Effects of pubertal development, height, weight, and grip strength on the bone mineral density of the lumbar spine and hip in peripubertal Japanese children: Kyoto kids increase density in the skeleton study (Kyoto KIDS study)
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DOI：
10.1007/s00774-005-0629-0
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发表时间：
2005-11-01
影响因子：
3.3
通讯作者：
Ikeda, Y
中科院分区：
文献类型：
--
作者：
Naka, H;Iki, M;Ikeda, Y
研究了生长发育和青春期发育对日本青春期儿童腰椎和髋部骨密度(BMD)的影响，以此作为评估可调节因素对骨量增加影响的基础。这项研究包括使用双能X射线骨密度仪测量腰椎(L2-4)、股骨颈和全髋部的骨量，以及身体尺寸测量和关于病史和青春期状况的详细访谈。受试者为三所初中的404名一年级学生(男生129人，女生275人，平均年龄12.8±0.3岁)，没有影响骨代谢的疾病或药物。各部位骨密度随体格发育和性成熟呈增加趋势。青春期前后男女儿童各骨骼部位骨密度与身高、体重、握力呈显著正相关。多元回归分析显示，青春期发育对女孩各骨骼部位骨密度均有显著正向独立影响，但对男孩无显著影响。身体和青春期发育对BMD有重大影响，但这些影响的大小在男孩和女孩中是不同的，即使他们的年龄相同。我们的结论是，在研究环境或行为因素对青春期儿童骨量获得的影响时，应对男孩和女孩以不同的方式考虑身体发育和青春期发育的混杂因素。
The effects of growth and pubertal development on the bone mineral density (BMD) of the lumbar spine and hip in peripubertal Japanese children were studied as a basis for evaluating the effects of modifiable factors on bone mass gain. The study comprised bone mass measurements in the lumbar spine (L2-4), femoral neck, and total hip using dual-energy X-ray absorptiometry as well as body size measurements and detailed interviews on medical history and pubertal status. The subjects were 404 first-grade students in three junior high schools (129 boys and 275 girls, mean age 12.8 +/- 0.3 years) with no diseases or medication that would affect bone metabolism. BMD at each site showed an increasing trend with physical growth and sexual maturity. Significant positive correlations were observed between BMD at every skeletal site and height, weight, and grip strength in pre- and postpubertal boys and girls. In multiple regression analyses, pubertal development had a significant positive independent effect on BMD at every skeletal site in girls, but not in boys. Physical and pubertal development showed major effects on BMD, but the magnitude of these effects differed in boys and girls, even if they were of the same age. We conclude that confounding factors due to physical and pubertal development should be taken into consideration in different ways for boys and girls in investigations on the effects of environmental or behavioral factors on bone mass acquisition in peripubertal children.