Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate
Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate
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DOI：
10.1039/c2sm07358g
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发表时间：
2012-01-01
期刊：
影响因子：
3.4
通讯作者：
Ces, Oscar
中科院分区：
文献类型：
--
作者：
Furse, Samuel;Brooks, Nicholas J.;Ces, Oscar
在本文中，我们提出的证据表明，磷脂酰肌醇4-磷酸诱导生物膜的曲率。已使用小角X-射线散射和生物相关的镁浓度的存在下，作为压力和温度的函数的二硬脂酰磷脂酰肌醇4-磷酸（DSPIP）和二油酰磷脂酰胆碱（DOPC）的混合物的相行为进行了研究。我们的研究结果表明，在生理相关的浓度（2摩尔%），DSPIP是能够诱导形成的反六方相（H-II）在很宽的范围内的条件。这一结果对磷脂酰肌醇脂质在体内的结构作用有影响。
In this paper we present evidence that phosphatidylinositol 4-phosphate induces curvature in biological membranes. The phase behaviour of mixtures of distearoylphosphatidylinositol 4-phosphate (DSPIP) and dioleoylphosphatidylcholine (DOPC) as a function of pressure and temperature has been studied using small-angle X-ray scattering and in the presence of biologically relevant magnesium concentrations. Our results demonstrate that at physiologically relevant concentrations (2 mol%), DSPIP is capable of inducing the formation of the inverse hexagonal phase (H-II) over a wide range of conditions. This result has implications for the structural role of phosphatidylinositol lipids in vivo.